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World J Cardiol. Jun 26, 2014; 6(6): 353-366
Published online Jun 26, 2014. doi: 10.4330/wjc.v6.i6.353
Essential hypertension and oxidative stress: New insights
Jaime González, Nicolás Valls, Roberto Brito, Ramón Rodrigo
Jaime González, Nicolás Valls, Roberto Brito, Ramón Rodrigo, Laboratory of Oxidative Stress and Nephrotoxicity, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Casilla 70058, Chile
Jaime González, Clinical Hospital, University of Chile, Casilla 70058, Chile
Author contributions: González J conducted the critical review of the evidence, wrote and revised the manuscript and designed figures; Valls N conducted the critical review of evidence, wrote the manuscript and designed tables; Brito R conducted the critical review of evidence and revised the manuscript; Rodrigo R wrote and revised the manuscript; all authors read and approved the final version of the manuscript.
Correspondence to: Ramón Rodrigo, MSc, Professor, Laboratory of Oxidative Stress and Nephrotoxicity, Molecular and Clinical Pharmacology Program, Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Independencia 1027, Santiago 7, Casilla 70058, Chile. rrodrigo@med.uchile.cl
Telephone: +56-2-9786126 Fax: +56-2-9786126
Received: December 1, 2013
Revised: March 1, 2014
Accepted: May 8, 2014
Published online: June 26, 2014
Processing time: 206 Days and 15.1 Hours
Core Tip

Core tip: This review focuses on one of the most prevalent diseases worldwide: hypertension, providing new insights about the key role of oxidative stress in the pathophysiology of essential hypertension and new clinical attempts to demonstrate the usefulness of antioxidant therapy in its treatment.