Systematic Review
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World J Cardiol. May 26, 2014; 6(5): 338-344
Published online May 26, 2014. doi: 10.4330/wjc.v6.i5.338
Heart and lung, a dangerous liaison-Tako-tsubo cardiomyopathy and respiratory diseases: A systematic review
Roberto Manfredini, Fabio Fabbian, Alfredo De Giorgi, Marco Pala, Alessandra Mallozzi Menegatti, Claudia Parisi, Elisa Misurati, Ruana Tiseo, Massimo Gallerani, Raffaella Salmi, Eduardo Bossone
Roberto Manfredini, Fabio Fabbian, Alfredo De Giorgi, Marco Pala, Alessandra Mallozzi Menegatti, Claudia Parisi, Elisa Misurati, Ruana Tiseo, Clinica Medica, Azienda Ospedaliera-Universitaria of Ferrara, 44124 Cona, Ferrara, Italy
Massimo Gallerani, 1st Internal Medicine Unit, Azienda Ospedaliera-Universitaria of Ferrara, 44124 Cona, Ferrara, Italy
Raffaella Salmi, 2nd Internal Medicine Unit, Azienda Ospedaliera-Universitaria of Ferrara, 44124 Cona, Ferrara, Italy
Eduardo Bossone, Cardiology Unit, Azienda Ospedaliera-Universitaria of Salerno, 84131 Salerno, Italy
Author contributions: Manfredini R and Bossone E equally contributed to the work; Manfredini R, Fabbian F, Gallerani M, Salmi R, Bossone E designed the research; De Giorgi A, Pala M, Mallozzi Menegatti A, Parisi C, Misurati E, Tiseo R searched the available literature, found the articles, and performed the research; Manfredini R, Fabbian F, De Giorgi A, Pala M, Mallozzi Menegatti A, Parisi C, Misurati E, Tiseo R analyzed the data; Manfredini R, Fabbian F, Bossone E, Gallerani M wrote the paper; Manfredini R, Fabbian F, De Giorgi A, Pala M, Mallozzi Menegatti A, Parisi C, Misurati E, Tiseo R, Gallerani M, Salmi R, Bossone E revised critically the manuscript for intellectual and conceptual content, and approved the final version; Manfredini R collected funds.
Supported by A scientific grant (FAR–Fondo Ateneo Ricerca) from the University of Ferrara, Italy (in part)
Correspondence to: Roberto Manfredini, MD, Clinica Medica, Azienda Ospedaliera-Universitaria of Ferrara, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy. roberto.manfredini@unife.it
Telephone: +39-0532-237166 Fax: +39-0532-236816
Received: December 21, 2013
Revised: March 11, 2014
Accepted: April 17, 2014
Published online: May 26, 2014
Processing time: 183 Days and 24 Hours
Core Tip

Core tip: This is the first study evaluating the association between respiratory diseases and Tako-Tsubo cardiomyopathy (TTC). Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC. Thus, in these patients a certain caution should maintained, along with a special alertness in suspecting and recognizing this particular disease.