Anselm DD, Evans JM, Baranchuk A. Brugada phenocopy: A new electrocardiogram phenomenon. World J Cardiol 2014; 6(3): 81-86 [PMID: 24669289 DOI: 10.4330/wjc.v6.i3.81]
Corresponding Author of This Article
Adrian Baranchuk, MD, FACC, FRCPC, Associate Professor of Medicine, Division of Cardiology, Electrophysiology and Pacing, Queen’s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada. barancha@kgh.kari.net
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Mar 26, 2014; 6(3): 81-86 Published online Mar 26, 2014. doi: 10.4330/wjc.v6.i3.81
Brugada phenocopy: A new electrocardiogram phenomenon
Daniel D Anselm, Jennifer M Evans, Adrian Baranchuk
Daniel D Anselm, Jennifer M Evans, Adrian Baranchuk, Division of Cardiology, Electrophysiology and Pacing, Queen’s University, Kingston General Hospital, Kingston, Ontario K7L 2V7, Canada
Author contributions: Anselm DD and Baranchuk A contributed equally to this work; Anselm DD wrote the manuscript including the initial draft and subsequent revisions; Evans JM revised the paper to meet grammatical and linguistic standards; Baranchuk A designed the manuscript, contributed to revisions and served as senior advisor; all authors read and approved the final manuscript.
Correspondence to: Adrian Baranchuk, MD, FACC, FRCPC, Associate Professor of Medicine, Division of Cardiology, Electrophysiology and Pacing, Queen’s University, Kingston General Hospital, 76 Stuart Street, Kingston, Ontario K7L 2V7, Canada. barancha@kgh.kari.net
Telephone: +1-613-5496666 Fax: +1-613-5481387
Received: November 11, 2013 Revised: December 24, 2013 Accepted: January 15, 2014 Published online: March 26, 2014 Processing time: 128 Days and 10.6 Hours
Core Tip
Core tip: Diagnostic distinctions between Brugada phenocopies (BrP) and Brugada syndrome (BrS) are: (1) BrP patients have a reversible underlying condition and upon resolution of this condition, the electrocardiogram normalizes; (2) BrP patients have a low pretest probability of BrS as opposed to a high pretest probability in patients with true congenital BrS; and (3) BrP patients have a negative sodium channel blocker test, while patients with BrS have a positive test. The different electrocardiographic response to the provocative challenge highlights a pathophysiological divergence when comparing BrP and BrS. This suggests alternative underlying mechanisms with various genetic, structural and environmental interactions yet to be elucidated.
