Minireviews
Copyright ©2014 Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Dec 26, 2014; 6(12): 1262-1269
Published online Dec 26, 2014. doi: 10.4330/wjc.v6.i12.1262
Implications of Klotho in vascular health and disease
Ernesto Martín-Núñez, Javier Donate-Correa, Mercedes Muros-de-Fuentes, Carmen Mora-Fernández, Juan F Navarro-González
Ernesto Martín-Núñez, Javier Donate-Correa, Carmen Mora-Fernández, Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Mercedes Muros-de-Fuentes, Clinical Analysis Service and Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Juan F Navarro-González, Nephrology Service and Research Unit, University Hospital Nuestra Señora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
Author contributions: Martín-Núñez E and Donate-Correa J reviewed the literature and drafted the manuscript; Muros-de-Fuentes M, Mora-Fernández C and Navarro-González JF reviewed and approved the manuscript.
Correspondence to: Juan F Navarro-González, MD, PhD, Research Unit, University Hospital Nuestra Señora de Candelaria, Carretera del Rosario, 38010 Santa Cruz de Tenerife, Spain. jnavgon@gobiernodecanarias.org
Telephone: +34-922-600566 Fax: +34-922-600562
Received: July 25, 2014
Revised: September 13, 2014
Accepted: October 1, 2014
Published online: December 26, 2014
Processing time: 156 Days and 16.4 Hours
Core Tip

Core tip: Cardiovascular disease (CVD) is the first cause of death worldwide. The anti-aging factor Klotho has been linked to the development of CVD since clinical studies relate circulating levels of Klotho with the appearance of vascular disease and different Klotho gene variants are associated with increased cardiovascular risk. Furthermore, Klotho is involved in promotion of vascular health through different mechanisms. The recent description of its expression in vascular tissue opens up new options for the treatment of cardiovascular diseases.