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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Cardiol. Jun 26, 2013; 5(6): 164-174
Published online Jun 26, 2013. doi: 10.4330/wjc.v5.i6.164
Published online Jun 26, 2013. doi: 10.4330/wjc.v5.i6.164
Peroxisome-proliferator-activated receptors regulate redox signaling in the cardiovascular system
Teayoun Kim, Qinglin Yang, Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, AL 35294-3360, United States
Author contributions: Kim T wrote part of manuscript and Yang Q completed, advised and edited this manuscript.
Supported by Grants from National Institutes of Health, 1R01 HL085499 to Yang Q, NO. 1R01 HL084456, and NO. T32 HL007457 to Kim T and the ADA Basic Science Award, #7-12-BS-208, to Yang Q
Correspondence to: Qinglin Yang, MD, PhD, Professor, Department of Nutrition Sciences, University of Alabama at Birmingham, 1675 University Blvd., Webb 435, Birmingham, AL 35294-3360, United States. qyang@uab.edu
Telephone: +1-205-9966022 Fax: +1-205-9347049
Received: February 20, 2013
Revised: April 6, 2013
Accepted: May 16, 2013
Published online: June 26, 2013
Processing time: 128 Days and 16 Hours
Revised: April 6, 2013
Accepted: May 16, 2013
Published online: June 26, 2013
Processing time: 128 Days and 16 Hours
Core Tip
Core tip: Numerous studies have shown that peroxisome-proliferator-activated receptors (PPARs) ligands can modulate antioxidants via various mechanisms. Importantly, direct transcriptional regulation of antioxidant genes, such as thioredoxin-1, glutathione peroxidase 3, sestrin-1, catalase, superoxide dismutase (SOD)1, SOD2, and heme oxygenase, is established by identifying functional PPAR responsive element in promoter regions of the above genes. This review summarizes how these important antioxidant genes are regulated by each subtype of PPARs in response to oxidative stress in the cardiovascular system and how oxidative stress affects PPAR function, as well as the biological implications in the cardiovascular system.