Brief Article
Copyright ©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Cardiol. Nov 26, 2013; 5(11): 426-433
Published online Nov 26, 2013. doi: 10.4330/wjc.v5.i11.426
Positive influence of aspirin on coronary endothelial function: Importance of the dose
Hiroki Teragawa, Naoya Mitsuba, Ken Ishibashi, Satoshi Kurisu, Yasuki Kihara
Hiroki Teragawa, Department of Cardiovascular Medicine, Hiroshima General Hospital of West Japan Railway Company, Hiroshima 732-0057, Japan
Naoya Mitsuba, Ken Ishibashi, Satoshi Kurisu, Yasuki Kihara, Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical Sciences, Hiroshima 734-8551, Japan
Author contributions: Teragawa H designed the study, collected data, and wrote the manuscript; Mitsuba N and Ishibashi K collected data; Kurisu S evaluated the study data; Kihara Y revised the manuscript and approved the final version of the manuscript.
Correspondence to: Hiroki Teragawa, MD, PhD, Department of Cardiovascular Medicine, Hiroshima General Hospital of West Japan Railway Company, 3-1-36 Futabanosato, Higashi-ku, Hiroshima 732-0057, Japan. hiroteraga71@gmail.com
Telephone: +81-82-2621171 Fax: +81-82-2621499
Received: July 30, 2013
Revised: September 29, 2013
Accepted: October 16, 2013
Published online: November 26, 2013
Processing time: 126 Days and 3.2 Hours
Core Tip

Core tip: We investigated the effect of aspirin on coronary endothelial function. Patients were distributed into Group I, who were administered aspirin and Group II, which was the control group. Group I was divided into Group Ia (low-dose aspirin) and Group Ib (high-dose aspirin). Acetylcholine (ACh)-induced coronary dilation was greater in Group I than in Group II and was greater in Group Ia than in Group Ib. Multivariate regression analysis showed that a low-dose of aspirin was associated with ACh-induced coronary dilation. A Low dose of aspirin has a positive influence on coronary endothelial function.