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World J Cardiol. Oct 26, 2013; 5(10): 394-396
Published online Oct 26, 2013. doi: 10.4330/wjc.v5.i10.394
Published online Oct 26, 2013. doi: 10.4330/wjc.v5.i10.394
Circle of Willis atherosclerosis, Alzheimer’s disease and the Dean number
Rovshan M Ismailov, Complex Mechanisms of Disease, Aging and Trauma (CMDAT) Research Foundation, Glendale, CO 80246, United States
Author contributions: Ismailov RM solely contributed to this paper.
Correspondence to: Rovshan M Ismailov, MD, MPH, PhD, Research Scientist, Complex Mechanisms of Disease, Aging and Trauma (CMDAT) Research Foundation, PO Box 461286, Glendale, CO 80246, United States. rovshani@yahoo.com
Telephone: +1-720-9753393 Fax: +1-720-9494866
Received: June 16, 2013
Revised: September 20, 2013
Accepted: October 11, 2013
Published online: October 26, 2013
Processing time: 129 Days and 10.6 Hours
Revised: September 20, 2013
Accepted: October 11, 2013
Published online: October 26, 2013
Processing time: 129 Days and 10.6 Hours
Core Tip
Core tip: The Dean number can become an important local pathophysiological mechanism that can help to explain the specific involvement of the Circle of Willis in atherosclerosis and Alzheimer’s Disease as anatomically different parts of the Circle of Willis would exhibit various degree of the curvature which would predispose to Alzheimer’s disease. This could possibly explain some sporadic cases of Alzheimer’s disease in the presence of minimal damage from atherosclerosis as well as open up new avenues for prevention of sporadic Alzheimer’s disease.