Li P, Zhang HP. Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications. World J Cardiol 2025; 17(5): 107320 [PMID: 40496387 DOI: 10.4330/wjc.v17.i5.107320]
Corresponding Author of This Article
Hui-Ping Zhang, MD, Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, Dongdan, Dongcheng District, Beijing 100730, China. huipingzhang73@163.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. May 26, 2025; 17(5): 107320 Published online May 26, 2025. doi: 10.4330/wjc.v17.i5.107320
Osteosarcopenia in older adults undergoing transcatheter aortic valve replacement: A narrative review of mortality and frailty implications
Peng Li, Hui-Ping Zhang
Peng Li, Department of Geriatrics, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
Hui-Ping Zhang, Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China
Author contributions: Li P performed the research and wrote this original manuscript; Zhang HP overseen the project; all of the authors read and approved the final version of the manuscript to be published.
Supported by National High Level Hospital Clinical Research Funding Project, No. BJ-2023-206.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hui-Ping Zhang, MD, Department of Cardiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 Dahua Road, Dongdan, Dongcheng District, Beijing 100730, China. huipingzhang73@163.com
Received: March 21, 2025 Revised: April 10, 2025 Accepted: May 7, 2025 Published online: May 26, 2025 Processing time: 64 Days and 2.6 Hours
Core Tip
Core Tip: Osteosarcopenia, the co-occurrence of muscle atrophy and bone density loss, is increasingly recognized as a potent marker of frailty in older adults undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. This review synthesizes evidence demonstrating that osteosarcopenia affects 15%-20% of TAVR patients and independently predicts 1-year mortality (P < 0.05). Compared to isolated sarcopenia or osteoporosis, osteosarcopenia correlates with higher risks of post-procedural complications, prolonged hospitalization, and functional decline. Key imaging biomarkers—psoas muscle cross-sectional area (muscle mass) and lumbar trabecular attenuation (bone density)—derived from pre-TAVR computed tomography scans provide objective frailty metrics. Integrating these parameters into risk stratification models (e.g., Society of Thoracic Surgeons Predicted Risk of Mortality) enhances predictive accuracy for adverse outcomes. Clinically, routine osteosarcopenia assessment could guide personalized interventions, such as resistance training and protein/vitamin D supplementation, to mitigate frailty-related risks. Early identification of osteosarcopenia bridges geriatric and cardiology care, offering a pathway to improve survival and quality of life in high-risk TAVR populations.
