Systematic Reviews
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Apr 26, 2025; 17(4): 104465
Published online Apr 26, 2025. doi: 10.4330/wjc.v17.i4.104465
Ivabradine in the treatment of congenital junctional ectopic tachycardia: A systematic review
Syed Faqeer Hussain Bokhari, Muhammad Muaz Mushtaq, Maham Mushtaq, Husnain Ali, Danyal Bakht, Muhayya Faizullah, Almas Asghar, Muhammad Khan Buhadur Ali, Muhammad Asad Sarwar, Maryyam Liaqat, Asma Iqbal, Wahidullah Dost
Syed Faqeer Hussain Bokhari, Muhammad Muaz Mushtaq, Maham Mushtaq, Husnain Ali, Danyal Bakht, Muhayya Faizullah, Almas Asghar, Muhammad Khan Buhadur Ali, Muhammad Asad Sarwar, Maryyam Liaqat, Asma Iqbal, Department of Medicine and Surgery, King Edward Medical University, Lahore 54000, Punjab, Pakistan
Wahidullah Dost, Curative Medicine, Kabul University of Medical Sciences, Kabul 10001, Afghanistan
Author contributions: Bokhari SFH led the conceptualization and overall supervision of the research, providing critical insights into study design and methodology; Mushtaq MM and Mushtaq M were responsible for literature search and data extraction, ensuring that relevant studies were systematically identified and analyzed; Ali H and Bakht D contributed to the statistical analysis and interpretation of findings, helping to establish the study's scientific rigor; Faizullah M and Asghar A were involved in manuscript drafting and revision, ensuring clarity and coherence in presenting the results; Ali MKB and Sarwar MA assisted in critical appraisal and quality assessment of the included studies, strengthening the reliability of the findings; Liaqat M and Iqbal A played a key role in formatting, referencing, and ensuring compliance with journal submission guidelines; Dost W contributed significantly to reviewing and editing the final manuscript, refining the discussion and conclusion to enhance the overall impact of the study. The collaborative efforts of all authors ensured a well-structured and comprehensive systematic review.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this systematic review.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wahidullah Dost, Curative Medicine, Kabul University of Medical Sciences, Kabul 10001, Afghanistan. wahidullahdost96@gmail.com
Received: December 23, 2024
Revised: March 11, 2025
Accepted: April 8, 2025
Published online: April 26, 2025
Processing time: 121 Days and 17.3 Hours
Core Tip

Core Tip: Ivabradine, a selective hyperpolarization-activated cyclic nucleotide-gated channel inhibitor, shows promise in managing congenital junctional ectopic tachycardia (CJET) in neonates and infants, especially when conventional antiarrhythmic therapies fail. This systematic review highlights ivabradine's efficacy in controlling heart rate, achieving sinus rhythm, and stabilizing junctional rhythm, with no significant adverse effects reported. Despite the encouraging results, further prospective studies with larger sample sizes and extended follow-up are necessary to establish ivabradine's definitive role in CJET management.