Systemic immune inflammation index as a predictor for atrial fibrillation recurrence after catheter ablation

doi:10.4330/wjc.v17.i3.103993

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Mar 26, 2025 (publication date) through Mar 21, 2025

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Mar 26, 2025; 17(3): 103993
Published online Mar 26, 2025. doi: 10.4330/wjc.v17.i3.103993

Systemic immune inflammation index as a predictor for atrial fibrillation recurrence after catheter ablation

Panayotis K Vlachakis, Panagiotis Theofilis, Athanasios Kordalis, Dimitris Tousoulis

Panayotis K Vlachakis, Panagiotis Theofilis, Athanasios Kordalis, Department of 1^st Cardiology, General Hospital of Athens “Hippocratio”, University of Athens Medical School, Athens 11527, Greece

Dimitris Tousoulis, Department of 1^st Cardiology, Athens Medical School, National and Kapodistrian University of Athens, Athens 11527, Greece

Author contributions: Vlachakis PK and Theofilis P conducted the literature search and wrote the original draft; Kordalis A and Tousoulis D supervised and critically revised the manuscript. All authors have read and agreed to the final version.

Conflict-of-interest statement: Authors declare no conflict of interests for this article.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Dimitris Tousoulis, Professor, Department of 1^st Cardiology, Athens Medical School, National and Kapodistrian University of Athens, Mantouvalou 3, Athens 11527, Greece. drtousoulis@hotmail.com

Received: December 6, 2024
Revised: February 14, 2025
Accepted: February 25, 2025
Published online: March 26, 2025
Processing time: 105 Days and 10.7 Hours

Core Tip

Core Tip: To optimize outcomes after catheter ablation for atrial fibrillation (Afib), understanding predictors of recurrence is crucial. The systemic immune inflammation index (SII) has emerged as a practical tool to identify patients at higher risk. This biomarker, based on neutrophil, lymphocyte, and platelet counts, reflects systemic inflammation-a key driver of atrial remodeling and recurrence. Integrating SII with existing scoring systems, like the APPLE score, enhances risk prediction and allows for personalized treatment strategies, promoting better long-term outcomes and targeted care for Afib patients.