Letter to the Editor
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Mar 26, 2025; 17(3): 103074
Published online Mar 26, 2025. doi: 10.4330/wjc.v17.i3.103074
Evaluating inflammatory status to predict atrial fibrillation recurrence following ablation: The role of systemic immune-inflammation index
Amedeo Tirandi, Federico Carbone, Luca Liberale, Fabrizio Montecucco
Amedeo Tirandi, Center for Molecular Cardiology, University of Zurich, Schlieren 8952, Zürich, Switzerland
Amedeo Tirandi, Federico Carbone, Luca Liberale, Fabrizio Montecucco, First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa 16132, Liguria, Italy
Federico Carbone, Luca Liberale, Fabrizio Montecucco, IRCCS Ospedale Policlinico San Martino, Genoa–Italian Cardiovascular Network, Genoa 16132, Liguria, Italy
Author contributions: Tirandi A wrote the paper and drew the image; Liberale L, Carbone F and Montecucco F supervised the entire work; all authors read the final version of the manuscript and approved it for submission and publication.
Conflict-of-interest statement: Liberale L is coinventor on the International Patent WO/2020/226993 filed in April 2020; the patent relates to the use of antibodies which specifically bind interleukin-1a to reduce various sequelae of ischemia-reperfusion injury to the central nervous system. Liberale L has received financial support from the Swiss Heart Foundation and the Novartis Foundation for Medical-Biological Research outside of this work. Tirandi A, Carbone F, and Montecucco F have no conflict of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Fabrizio Montecucco, MD, PhD, Professor, First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, 6 Viale Benedetto XV, Genoa 16132, Liguria, Italy. fabrizio.montecucco@unige.it
Received: November 12, 2024
Revised: March 6, 2025
Accepted: March 12, 2025
Published online: March 26, 2025
Processing time: 134 Days and 15 Hours
Core Tip

Core Tip: Atrial fibrillation (AF) recurrence may occur in more than one-third of patients after radiofrequency catheter ablation. Identifying patients at higher risk of recurrence allows for closer monitoring of those at high risk. The APPLE score has already been validated for this purpose. However, inflammation appears to play a crucial role in AF recurrence in this context. Wang et al combined the systemic immune inflammation index with the APPLE score showing a better predictivity of AF recurrence after ablation.