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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Mar 26, 2025; 17(3): 100290
Published online Mar 26, 2025. doi: 10.4330/wjc.v17.i3.100290
Published online Mar 26, 2025. doi: 10.4330/wjc.v17.i3.100290
Nexilin mutations, a cause of chronic heart failure: A state-of-the-art review starting from a clinical case
Oana-Cornelia Năstasie, Sebastian Onciul, Marian-Bogdan Drăgoescu, Nicoleta-Monica Popa-Fotea, Department of Cardiology, Clinical Emergency Hospital, Bucharest 014461, Romania
Dan-Andrei Radu, Laboratory of Interventional Cardiology, Carol Davila Central Military University Emergency Hospital, Bucharest 010825, Romania
Dan-Andrei Radu, Sebastian Onciul, Nicoleta-Monica Popa-Fotea, Cardio-Thoracic Department, University of Medicine and Pharmacy “Carol Davila”, Bucharest 050474, Romania
Co-first authors: Oana-Cornelia Năstasie and Dan-Andrei Radu.
Author contributions: Năstasie OC, Radu DA, Onciul S, Drăgoescu MB, and Popa-Fotea NM collected and analyzed the data; Popa-Fotea NM drafted the article; Năstasie OC, Radu DA, and Popa-Fotea NM conceived and designed the study, revised the manuscript for important intellectual content; Năstasie OC and Radu DA contributed equally as co-first authors; and all authors read and approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nicoleta-Monica Popa-Fotea, MD, PhD, Department of Cardiology, Clinical Emergency Hospital, 8 Floreasca Street, Bucharest 014461, Romania.
Received: August 12, 2024
Revised: January 12, 2025
Accepted: February 18, 2025
Published online: March 26, 2025
Processing time: 220 Days and 16.7 Hours
Revised: January 12, 2025
Accepted: February 18, 2025
Published online: March 26, 2025
Processing time: 220 Days and 16.7 Hours
Core Tip
Core Tip: Cardiomyopathies are a leading cause of heart failure, a condition marked by high morbidity and mortality despite continuous advancements in diagnosis and treatment. This review provides a succinct overview of cardiomyopathies, with a particular emphasis on their genetic origins - specifically, nexilin cardiomyopathy - highlighted through the case of a patient diagnosed with this condition. Existing research provides scarce information on individuals carrying nexilin mutations, and the relationship between this gene and cardiomyopathies continues to be actively investigated.