Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2024; 16(9): 496-501
Published online Sep 26, 2024. doi: 10.4330/wjc.v16.i9.496
Hypertrophic cardiomyopathy and left ventricular non-compaction: Distinct diseases or variant phenotypes of a single condition?
Natalia Przytuła, Ewa Dziewięcka, Mateusz Winiarczyk, Katarzyna Graczyk, Agnieszka Stępień, Paweł Rubiś
Natalia Przytuła, Ewa Dziewięcka, Mateusz Winiarczyk, Katarzyna Graczyk, Agnieszka Stępień, Paweł Rubiś, Department of Cardiac and Vascular Diseases, Saint John Paul II Hospital, Krakow 31-202, MA, Poland
Ewa Dziewięcka, Mateusz Winiarczyk, Katarzyna Graczyk, Agnieszka Stępień, Paweł Rubiś, Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Collegium Medicum, Saint John Paul II Hospital, Krakow 31-202, MA, Poland
Author contributions: Dziewięcka E and Rubiś P were responsible for conceptualization, methodology, and funding acquisition; Rubiś P was responsible for validation and supervision; Dziewięcka E was responsible for formal analysis, writing review, editing, and project administration; Przytuła N, Dziewięcka E, Winiarczyk M, Graczyk K, and Stępień A were responsible for investigation and data curation; Przytuła N was responsible for writing original draft preparation; all authors have read and agreed to the published version of the manuscript.
Supported by The Department of Scientific Research and Structural Funds of Medical College, Jagiellonian University, No. N41/DBS/000594.
Conflict-of-interest statement: The Authors declare no conflict of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ewa Dziewięcka, MD, PhD, Doctor, Department of Cardiac and Vascular Diseases, Institute of Cardiology, Jagiellonian University Collegium Medicum, Saint John Paul II Hospital, 80 Prądnicka Street, Krakow 31-202, MA, Poland. ewa@dziewiecka.pl
Received: May 27, 2024
Revised: August 2, 2024
Accepted: August 21, 2024
Published online: September 26, 2024
Processing time: 114 Days and 14.4 Hours
Core Tip

Core Tip: Hypertrophic cardiomyopathy (HCM) is a genetic myocardial disease marked by increased left ventricle (LV) wall thickness in the absence of abnormal loading conditions. Differentiating HCM from other conditions with LV hypertrophy, such as hypertension, aortic stenosis, or LV non-compaction (LVNC), can be challenging. LVNC is characterized by excessive LV trabeculation and deep recesses, affecting up to 5% of the general population. While typically benign, LVNC can occasionally lead to systolic dysfunction and arterial embolism. The overlap between HCM and LVNC, including genetic mutations and clinical features, raises the question of whether they are distinct diseases or variations of the same condition.