Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

doi:10.4330/wjc.v16.i7.422

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical and Translational Research

World J Cardiol. Jul 26, 2024; 16(7): 422-435
Published online Jul 26, 2024. doi: 10.4330/wjc.v16.i7.422

Network pharmacology-based exploration of molecular mechanisms underlying therapeutic effects of Jianpi Huatan Quyu recipe on chronic heart failure with spleen Qi deficiency syndrome

Si-Qi Li, Dong-Yu Min, Jun-Wen Jiang, Xiao-Ying Li, Xu-Na Yang, Wen-Bo Gu, Jia-Hui Jiang, Li-Hao Chen, Han Nan, Ze-Yu Chen

Si-Qi Li, Dong-Yu Min, Jun-Wen Jiang, Xiao-Ying Li, Xu-Na Yang, Wen-Bo Gu, Jia-Hui Jiang, Li-Hao Chen, Han Nan, Ze-Yu Chen, Second Department of Cardiology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110000, Liaoning Province, China

Author contributions: Li SQ designed the study and drafted the manuscript; all authors contributed to revising and proofreading the manuscript.

Supported by 2021 Shenyang Science and Technology Program-Public Health R&D Special Project (Joint Project) of Shenyang Municipal Science and Technology Bureau, No. 21-174-9-04.

Conflict-of-interest statement: There is no conflict of interest to disclose.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Si-Qi Li, MD, Chief Physician, Second Department of Cardiology, The Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33 Beiling Street, Huanggu District, Shenyang 110000, Liaoning Province, China. pangdun66@163.com

Received: May 23, 2024
Revised: July 2, 2024
Accepted: July 4, 2024
Published online: July 26, 2024
Processing time: 62 Days and 5.4 Hours

Core Tip

Core Tip: Based on the clinical characteristics of patients, the dialectical treatment of chronic heart failure is often performed primarily by strengthening Qi and nourishing Yin, promoting blood circulation and removing blood stasis, resolving phlegm and alleviating water retention, and warming and tonifying heart Yang. In this study, the authors found that the Chinese medicine compound preparation Jianpi Huatan Quyu recipe exerts therapeutic effects on chronic heart failure possibly by influencing the mitochondrial structure of cardiomyocytes, oxidative stress, energy metabolism, and other processes.