Hypoxia-inducible factor-1α in myocardial infarction

doi:10.4330/wjc.v16.i4.181

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Apr 26, 2024 (publication date) through Jul 4, 2024

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World Journal of Cardiology

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1949-8462

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Cardiol. Apr 26, 2024; 16(4): 181-185
Published online Apr 26, 2024. doi: 10.4330/wjc.v16.i4.181

Hypoxia-inducible factor-1α in myocardial infarction

Ivana Škrlec, Sergey N Kolomeichuk

Ivana Škrlec, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek 31000, Croatia

Sergey N Kolomeichuk, Institute of Biology, Karelia Research Center of Russian Academy of Sciences, Petrozavodsk 185910, Russia

Sergey N Kolomeichuk, Laboratory for Genomics, Proteomics, and Metabolomics, Research Institute of Biomedicine and Biomedical Technologies, Tyumen State Medical University, Tyumen 625023, Russia

Author contributions: Škrlec I did the majority of the writing and prepared the figure; Kolomeychuk SN did some writing and text editing.

Supported by Croatian Ministry of Science and Education, Josip Juraj Strossmayer University of Osijek, Faculty of Dental Medicine and Health, Osijek, Croatia, No. IP7-FDMZ-2023; West-Siberian Science and Education Center, Government of Tyumen District, Decree of 20.11.2020, No. 928-rp; and Ministry of Science and Higher Education, No. FMEN 2022-0009.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Ivana Škrlec, MSc, PhD, Assistant Professor, Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Crkvena 21, Osijek 31000, Croatia. iskrlec@fdmz.hr

Received: December 13, 2023
Peer-review started: December 13, 2023
First decision: January 15, 2024
Revised: January 26, 2024
Accepted: March 4, 2024
Article in press: March 4, 2024
Published online: April 26, 2024
Processing time: 131 Days and 23.5 Hours

Core Tip

Core Tip: Hypoxia-inducible factor 1 (HIF1), a versatile transcription factor, is crucial for the maintenance of oxygen homeostasis. Genetic variations in HIF1α may influence tissue response to hypoxia and affect clinical manifestations of coronary atherosclerosis. Research has confirmed that sufficient HIF1α expression leads to reperfusion in the ischemic skeletal muscle, whereas decreased expression is associated with hypoxic skin wounds in diabetic animal models. In addition, the HIF1α response can be influenced by circadian proteins. Interpretation of circadian and hypoxia signaling pathways may enable therapeutic interventions in diseases associated with oxygen deprivation, including myocardial infarction.