Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jan 26, 2024; 16(1): 16-26
Published online Jan 26, 2024. doi: 10.4330/wjc.v16.i1.16
Do changes in intracoronary pressure aid coronary spasm diagnosis using the spasm provocation test?
Hiroki Teragawa, Chikage Oshita, Yuko Uchimura
Hiroki Teragawa, Chikage Oshita, Yuko Uchimura, Department of Cardiovascular Medicine, JR Hiroshima Hospital, Hiroshima 732-0057, Japan
Author contributions: Oshita C and Uchimura Y contributed to the acquisition of data and Teragawa H contributed to the writing and revision of the manuscript; All the authors approved the final version of the manuscript.
Institutional review board statement: The study was reviewed and approved by the JR Hiroshima Hospital Institutional Review Board, No. 2023-11.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Hiroki Teragawa, Yuko Uchimura and Chikage Oshita have no Conflict-of-interest statement regarding the present manuscript.
Data sharing statement: No additional data not shown in this paper are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Hiroki Teragawa, FACC, FACP, FAHA, FESC, MD, PhD, Chief Physician, Doctor, Department of Cardiovascular Medicine, JR Hiroshima Hospital, 3-1-36 Futabanosato, Higashi-ku, Hiroshima 732-0057, Japan. hiroki-teragawa@jrhh.or.jp
Received: September 27, 2023
Peer-review started: September 27, 2023
First decision: November 28, 2023
Revised: December 11, 2023
Accepted: December 28, 2023
Article in press: December 28, 2023
Published online: January 26, 2024
Processing time: 113 Days and 4.8 Hours
Core Tip

Core Tip: The spasm provocation test (SPT) is a well-established tool for diagnosing coronary spasms. However, it is associated with several complications that can make the test a stressful experience. We investigated whether coronary spasms detected in the SPT can be estimated using intracoronary artery pressure measured with a pressure wire. We found that coronary spasms induced by low acetylcholine doses were associated with decreased intracoronary pressure at baseline. Coronary spasms induced by moderate-to-high acetylcholine doses showed decreased intracoronary pressure from baseline to low acetylcholine doses. These indices of intracoronary pressure may be used to predict coronary spasms.