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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. May 26, 2023; 15(5): 253-261
Published online May 26, 2023. doi: 10.4330/wjc.v15.i5.253
Published online May 26, 2023. doi: 10.4330/wjc.v15.i5.253
Importance of concomitant functional mitral regurgitation on survival in severe aortic stenosis patients undergoing aortic valve replacement
Ramdas G Pai, Department of Cardiology, University of California Riverside School of Medicine, Riverside/St. Bernardine Medical Center, San Bernardino, Riverside, CA 92521, United States
Padmini Varadarajan, Department of Cardiology, University of California Riverside School of Medicine, Riverside, CA 92521, United States
Author contributions: Pai RG and Varadarajan P designed the study, analyzed the data, wrote the manuscript and revised the final form.
Institutional review board statement: The research project was approved by the institutional review board of Loma Linda University, Loma Linda, California.
Informed consent statement: A need for an informed consent was waived because of its retrospective, observational study design without any intervention.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ramdas G Pai, FACC, FRCP (Hon), MD, Doctor, Professor, Department of Cardiology, University of California Riverside School of Medicine, Riverside/St. Bernardine Medical Center, San Bernardino, Riverside, CA 92507, United States. ramdaspai@yahoo.com
Received: December 20, 2022
Peer-review started: December 20, 2022
First decision: February 20, 2023
Revised: March 20, 2023
Accepted: April 25, 2023
Article in press: April 25, 2023
Published online: May 26, 2023
Peer-review started: December 20, 2022
First decision: February 20, 2023
Revised: March 20, 2023
Accepted: April 25, 2023
Article in press: April 25, 2023
Published online: May 26, 2023
Core Tip
Core Tip: This study is unique in several aspects: (1) Shows that mitral regurgitation negatively impacts survival in an independent fashion, an effect incremental to left ventricular size and ejection fraction; (2) Perhaps the longest follow up of severe aortic stenosis (AS) patients undergoing aortic valve replacement (AVR) (till death or 16-26 year follow up in survivors); (3) Gives insights into potential mitral regurgitation (MR) mechanisms; and (4) Validates echocardiographic MR severity against survival in patients with severe AS undergoing AVR.