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World J Cardiol. May 26, 2023; 15(5): 217-228
Published online May 26, 2023. doi: 10.4330/wjc.v15.i5.217
Acute heart failure as an adverse event of tumor necrosis factor inhibitor therapy in inflammatory bowel disease: A review of the literature
Thais Gagno Grillo, Caroline Ferreira da Silva Mazeto Pupo Silveira, Ana Elisa Valencise Quaglio, Renata de Medeiros Dutra, Julio Pinheiro Baima, Silmeia Garcia Zanati Bazan, Ligia Yukie Sassaki
Thais Gagno Grillo, Caroline Ferreira da Silva Mazeto Pupo Silveira, Renata de Medeiros Dutra, Julio Pinheiro Baima, Silmeia Garcia Zanati Bazan, Ligia Yukie Sassaki, Department of Internal Medicine, Medical School, São Paulo State University, Botucatu, Botucatu 18618686, Brazil
Ana Elisa Valencise Quaglio, Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University, Botucatu, Botucatu 18618689, Brazil
Author contributions: Grillo TG, Silveira CFDSMP, Quaglio AEV, Dutra RM, Baima JP, and Bazan SGZ undertook the majority of the writing; Sassaki LY designed the outline and coordinated the writing of the paper; all authors revised the manuscript for important intellectual content and approved the final version.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ligia Yukie Sassaki, MD, PhD, Assistant Professor, Full Professor, Department of Internal Medicine, Medical School, São Paulo State University, Mário Rubens Guimarães Montenegro, Botucatu, Botucatu 18618686, Brazil. ligia.sassaki@unesp.br
Received: January 16, 2023
Peer-review started: January 16, 2023
First decision: January 30, 2023
Revised: February 9, 2023
Accepted: April 12, 2023
Article in press: April 12, 2023
Published online: May 26, 2023
Processing time: 122 Days and 11.2 Hours
Core Tip

Core Tip: Tumor necrosis factor inhibitors (anti-TNFs) are widely used for the treatment of inflammatory bowel diseases (IBD). However, heart failure, although rare, is an adverse event associated with the use of anti-TNFs in these patients. This review discusses the adverse events, especially heart failure, associated with the administration of anti-TNF therapy. We believe that our study makes a significant contribution to the literature because it discusses the current understanding in the field and proposes approaches to avoid the occurrence of adverse events due to anti-TNFs in patients with IBD.