Systematic Reviews
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Apr 26, 2023; 15(4): 184-199
Published online Apr 26, 2023. doi: 10.4330/wjc.v15.i4.184
Effectiveness of high intensity interval training on cardiorespiratory fitness and endothelial function in type 2 diabetes: A systematic review
Christos Kourek, Eleftherios Karatzanos, Vasiliki Raidou, Ourania Papazachou, Anastassios Philippou, Serafim Nanas, Stavros Dimopoulos
Christos Kourek, Eleftherios Karatzanos, Anastassios Philippou, Serafim Nanas, Stavros Dimopoulos, Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1st Critical Care Medicine Department, Evangelismos Hospital, Athens 10676, Greece
Christos Kourek, Department of Cardiology, 417 Army Share Fund Hospital of Athens, Athens 11521, Greece
Vasiliki Raidou, Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, National and Kapodistrian University of Athens, Athens 10676, Greece
Ourania Papazachou, Department of Cardiology, "Helena Venizelou" Hospital, Athens 10676, Greece
Anastassios Philippou, Department of Physiology, School of Medicine, National and Kapodistrian University of Athens, Athens 11527, Greece
Stavros Dimopoulos, Cardiac Surgery Intensive Care Unit, Onassis Cardiac Surgery Center, Athens 17674, Greece
Author contributions: Dimopoulos S designed the research; Kourek C performed the research; Kourek C, and Dimopoulos S analysed the data; Kourek C wrote the paper; All authors revised the paper.
Conflict-of-interest statement: All the authors received no financial support for the research, authorship, and/or publication of this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Stavros Dimopoulos, MD, PhD, Director, Research Scientist, Clinical Ergospirometry, Exercise and Rehabilitation Laboratory, 1st Critical Care Medicine Department, Evangelismos Hospital, 45-47 Ipsilantou Street, Athens 10676, Greece. stdimop@med.uoa.gr
Received: January 29, 2023
Peer-review started: January 29, 2023
First decision: February 8, 2023
Revised: February 22, 2023
Accepted: March 29, 2023
Article in press: March 29, 2023
Published online: April 26, 2023
Processing time: 80 Days and 14.5 Hours
Core Tip

Core Tip: Beneficial effects of high intensity interval training (HIIT) in patients with type 2 diabetes mellitus (T2DM) still remain under investigation and number of studies is limited. We investigated the effectiveness of HIIT on cardiorespiratory fitness and endothelial function in patients with T2DM. We observed that regular aerobic exercise training has beneficial effects on peak VO2 and flow-mediated dilation in type 2 diabetic patients. Moreover, HIIT may be superior by improving these parameters to a greater extent than moderate-intensity continuous training.