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World J Cardiol. Jul 26, 2022; 14(7): 382-391
Published online Jul 26, 2022. doi: 10.4330/wjc.v14.i7.382
COVID-19 vaccine-associated myocarditis
Michael C Morgan, Lavannya Atri, Sean Harrell, Wael Al-Jaroudi, Adam Berman
Michael C Morgan, Lavannya Atri, Sean Harrell, Wael Al-Jaroudi, Division of Cardiology, Medical College of Georgia, Augusta, GA 30912, United States
Adam Berman, Baptist Heart, Baptist Medical Center, Jackson, MS 39202, United States
Adam Berman, Department of Population Health Sciences, Medical College of Georgia, Augusta, GA 30912, United States
Author contributions: Morgan MC and Atri L wrote the paper; Harrell S, Al-Jaroudi W and Berman A made critical revisions and added content to the manuscript; Berman A conceived the topic and provided oversight of the writing, editing and submission process.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Michael C Morgan, BSc, Division of Cardiology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912, United States. mimorgan@augusta.edu
Received: January 16, 2022
Peer-review started: January 16, 2022
First decision: March 16, 2022
Revised: March 30, 2022
Accepted: June 18, 2022
Article in press: June 18, 2022
Published online: July 26, 2022
Processing time: 185 Days and 0.9 Hours
Core Tip

Core Tip: In this review article, we aim to synthesize the current literature surrounding coronavirus disease 2019 (COVID-19) vaccine-mediated myocarditis. COVID-19 mRNA vaccination has been associated with increased cases of myocarditis, particularly in the adolescent and young adult male population. Presentation typically occurs several days following administration of the second dose of a COVID-19 mRNA vaccination. As the world continues to vaccinate against COVID-19, understanding this vaccine-related adverse event is clinically important. Potential mechanisms are reviewed, and current clinical recommendations are discussed.