Retrospective Study
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Sep 26, 2021; 13(9): 483-492
Published online Sep 26, 2021. doi: 10.4330/wjc.v13.i9.483
Patients’ time in therapeutic range on warfarin among atrial fibrillation patients in Warfarin Medication Therapy Adherence Clinic
Siew Ling Lee, Thien Jian Ong, Wardati Mazlan-Kepli, Annuysia Mageswaran, Kai Hsin Tan, Abdul-Muizz Abd-Malek, Robert Cronshaw
Siew Ling Lee, Thien Jian Ong, Wardati Mazlan-Kepli, Annuysia Mageswaran, Kai Hsin Tan, Department of Pharmacy, Hospital Serdang, Ministry of Health Malaysia, Kajang 43000, Selangor, Malaysia
Abdul-Muizz Abd-Malek, Department of Cardiology, Hospital Serdang, Ministry of Health Malaysia, Kajang 43000, Selangor, Malaysia
Robert Cronshaw, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G128QQ, United Kingdom
Author contributions: Mazlan-Kepli W contributed to the idea and study design; Siew-Ling L, Thien-Jian O, and Annuysia M contributed to and performed all data analyses and interpretation of results; Siew-Ling L and Thien-Jian O wrote the first manuscript; Wardati MK contributed to the interpretation of results and critically reviewed the final manuscript; All authors contributed to the review of an approved manuscript before submission.
Institutional review board statement: Ethical approval for this study was obtained from the Medical Research and Ethics Committee (MREC), Ministry of Health Malaysia (NMRR-19-839-46462).
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment. Permission to use the patient data from this facility has been obtained from the Head of Department of Cardiology, Hospital Serdang.
Conflict-of-interest statement: The authors have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Siew Ling Lee, BPharm, Pharmacist, Department of Pharmacy, Hospital Serdang, Ministry of Health Malaysia, Jalan Puchong, Kajang 43000, Selangor, Malaysia. siewling.phc@gmail.com
Received: March 10, 2021
Peer-review started: March 10, 2021
First decision: May 6, 2021
Revised: May 25, 2021
Accepted: July 26, 2021
Article in press: July 26, 2021
Published online: September 26, 2021
Processing time: 192 Days and 2.3 Hours
Core Tip

Core Tip: This is a retrospective observational study to determine time in therapeutic range (TTR) and the predictors of poor TTR among patients with atrial fibrillation under follow-up at the Warfarin Medication Therapeutic Adherence Clinic of a tertiary cardiology referral center in Selangor, Malaysia. In this study cohort, we found that high HAS-BLED score (≥ 3) was a significant predictor of poor TTR.