Retrospective Study
Copyright ©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Nov 26, 2020; 12(11): 513-525
Published online Nov 26, 2020. doi: 10.4330/wjc.v12.i11.513
Effectiveness and safety of antithrombotic strategies in elderly patients with acute myocardial infarction
Elisa Rondano, Marzia Bertolazzi, Alessandro Galluzzo, Ludovica Maltese, Paolo Caccianotti, Sergio Macciò, Stefano Mazza, Maria Virginia Di Ruocco, Serena Favretto, Eraldo Occhetta, Francesco Rametta
Elisa Rondano, Marzia Bertolazzi, Alessandro Galluzzo, Ludovica Maltese, Paolo Caccianotti, Sergio Macciò, Stefano Mazza, Maria Virginia Di Ruocco, Serena Favretto, Eraldo Occhetta, Francesco Rametta, Cardiology Department, St. Andrea Hospital, Vercelli 13100, Italy
Author contributions: Rondano E, Bertolazzi M, Rametta F designed the research; Occhetta E approved the research, Rondano E, Bertolazzi M, Galluzzo A, Maltese L, Caccianotti P, Macciò S, Mazza S, Di Ruocco MV, Favretto S performed the research and contributed to data acquisition; Rondano E, Bertolazzi M, Galluzzo A, Occhetta E, Maltese L analyzed the data; Rondano E, Bertolazzi M, Galluzzo A, Maltese L wrote the paper; Occhetta E and Rametta F revised the paper; and all authors approved the final version of the article.
Institutional review board statement: The study was reviewed and approved for publication by our Institutional Reviewer.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrolment.
Conflict-of-interest statement: All the authors have no conflict of interest related to the manuscript.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Alessandro Galluzzo, MD, Doctor, Cardiology Department, St. Andrea Hospital, Corso Mario Abbiate 21, Vercelli 13100, Italy. alessandro.galluzzo@unito.it
Received: April 13, 2020
Peer-review started: April 13, 2020
First decision: April 26, 2020
Revised: July 28, 2020
Accepted: October 12, 2020
Article in press: October 12, 2020
Published online: November 26, 2020
Processing time: 226 Days and 17.8 Hours
Core Tip

Core Tip: This real-world study focuses on the difficult but common scenario of elderly patients admitted with acute myocardial infarction (AMI), for which literature evidence is lacking. We retrospectively identified 105 patients older than 80 years admitted for AMI. An invasive revascularization strategy was weighed considering the ischemic/hemorrhagic risk and was more common in ST-elevation myocardial infarction than in non-ST-elevation myocardial infarction patients. Despite the significant prevalence of atrial fibrillation and concomitant treatment with oral anticoagulation, the rates of in-hospital and 1-year cardiovascular death, ischemic and bleeding events were lower than those described previously, underlying the importance of a tailored therapeutic approach in this population.