Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Feb 26, 2019; 11(2): 57-70
Published online Feb 26, 2019. doi: 10.4330/wjc.v11.i2.57
Percutaneous devices for left atrial appendage occlusion: A contemporary review
Homam Moussa Pacha, Yasser Al-khadra, Mohamad Soud, Fahed Darmoch, Abdulghani Moussa Pacha, M Chadi Alraies
Homam Moussa Pacha, Mohamad Soud, MedStar Washington Hospital Center, Washington, DC 20010, United States
Yasser Al-khadra, Cleveland Clinic, Medicine Institute, Cleveland, OH 44195, United States
Fahed Darmoch, Beth Israel Deaconess Medical center/Harvard Medical School, Boston, MA 02215, United States
Abdulghani Moussa Pacha, University Hospital of Mainz, Mainz 55122, Germany
M Chadi Alraies, Wayne State University, Detroit Medical Center, Detroit Heart Hospital, Detroit, MI 48201, United States
Author contributions: All authors equally contributed to this paper with conception and design of the study, literature review and analysis, drafting and critical revision and editing, and final approval of the final version.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: M Chadi Alraies, MD, Wayne State University, Detroit Medical Center, Detroit Heart Hospital, 311 Mack Ave, Detroit, MI 48201, United States. makraies@dmc.org
Telephone: +1-216-2550008 Fax: +1-313-7453500
Received: October 16, 2018
Peer-review started: October 16, 2018
First decision: October 26, 2018
Revised: December 12, 2018
Accepted: December 17, 2018
Article in press: December 17, 2018
Published online: February 26, 2019
Processing time: 132 Days and 14 Hours
Core Tip

Core tip: Left atrial appendage occlusion (LAAO) is a reasonable alternative approach that is used in patients with atrial fibrillation who are not candidates for anticoagulation. A number of key trials have shown that Watchman device is non-inferior to warfarin therapy in preventing ischemic stroke/systemic thromboembolism. However, it is associated with lower rates of hemorrhagic stroke, bleeding and death. Multiple retrospective and prospective studies of Amplatzer device (ACP and Amulet) reported high success rates in device implantation and stroke prevention. Our objective is to consolidate the current literature to better delineate the safety, efficacy and indication of LAAO for stroke prevention.