Wiernek SL, Jiang B, Gustafson GM, Dai X. Cardiac implications of thrombotic thrombocytopenic purpura. World J Cardiol 2018; 10(12): 254-266 [PMID: 30622684 DOI: 10.4330/wjc.v10.i12.254]
Corresponding Author of This Article
Xuming Dai, FACC, MD, PhD, Attending Doctor, Division of Cardiology, New York Presbyterian Medical Group – Queens, 56-45 Main Street, Flushing, NY 11355, United States. xud9002@nyp.org
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Review
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Dec 26, 2018; 10(12): 254-266 Published online Dec 26, 2018. doi: 10.4330/wjc.v10.i12.254
Cardiac implications of thrombotic thrombocytopenic purpura
Szymon L Wiernek, Bo Jiang, Gregory M Gustafson, Xuming Dai
Szymon L Wiernek, Bo Jiang, Division of Cardiology, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, United States
Gregory M Gustafson, Xuming Dai, Division of Cardiology, Lang Research Center, New York Presbyterian Medical Group – Queens Hospital, Flushing, NY 11355, United States
Author contributions: Wiernek SL searched and reviewed literature, wrote the initial draft and participated revisions; Jiang B searched and reviewed literature, participated manuscript writing and revisions; Gustafson GM carefully reviewed the content of the manuscript, participated revisions, in particular, focused on language editing; Dai X initiated and proposed manuscript concept, participated literature search and review, wrote and revised manuscript as a senior author.
Conflict-of-interest statement: All authors declared no potential conflicts of interest relevant to this manuscript.
Open-Access: This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Xuming Dai, FACC, MD, PhD, Attending Doctor, Division of Cardiology, New York Presbyterian Medical Group – Queens, 56-45 Main Street, Flushing, NY 11355, United States. xud9002@nyp.org
Telephone: +1-718-6701724 Fax: +1-718-4457473
Received: August 28, 2018 Peer-review started: August 28, 2018 First decision: October 16, 2018 Revised: November 20, 2018 Accepted: November 26, 2018 Article in press: November 26, 2018 Published online: December 26, 2018 Processing time: 120 Days and 6.8 Hours
Core Tip
Core tip: Thrombotic thrombocytopenic purpura (TTP) is a grave medical condition caused by the formation of von Willebrand factor multimers that cause large platelet plugs and diffuse microemboli, leading to life-threatening, multi-organ ischemic injuries. Although cardiac involvement commonly occurs related to TTP, these cardiac manifestations have not been well studied and may thus be overlooked in clinical practice. Management of cardiac ischemia or myocardial infarction in TTP is also challenging due to increased hemorrhagic risk in the setting of thrombocytopenia. In this report, we systematically review available clinical data in the literature and summarize clinical manifestation, diagnostic workup strategies, prognosis, and the outcomes of cardiac involvement of TTP. We provide recommendations on the strategies for clinical assessment and management of TTP patients with cardiac involvement.
