Clinical Trials Study
Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Nov 26, 2018; 10(11): 222-233
Published online Nov 26, 2018. doi: 10.4330/wjc.v10.i11.222
Safety and efficacy of frequency-domain optical coherence tomography in evaluating and treating intermediate coronary lesions
Mohammad Reeaze Khurwolah, Hao-Yu Meng, Yong-Sheng Wang, Lian-Sheng Wang, Xiang-Qing Kong
Mohammad Reeaze Khurwolah, Hao-Yu Meng, Yong-Sheng Wang, Lian-Sheng Wang, Xiang-Qing Kong, Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Author contributions: Khurwolah MR, Meng HY, Wang YS, Wang LS and Kong XQ designed the research; Khurwolah MR, Meng HY and Wang LS performed the research; Khurwolah MR, Wang YS and Kong XQ analyzed the data; Khurwolah MR and Meng HY contributed equally to the study; Wang LS and Kong XQ supervised the study to an equal extent in the capacity of senior cardiology consultants; Khurwolah MR wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81570363; the National Key Research and Development Program of China, No. 2016YFA0201304; and the Priority Academic Program Development of Jiangsu Higher Education Institutions, No. KYZZ15_0263.
Institutional review board statement: The study protocol was reviewed and approved by the ethics committee of the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China (Ethics Approval ID: 2017-SR-328).
Clinical trial registration statement: The study is registered in the ClinicalTrials.gov Protocol Registration and Results System (PRS). ClinicalTrials.gov ID: NCT03229993.
Informed consent statement: All participants in the study provided informed consent, and the investigation was conducted in accordance with the World Medical Association Declaration of Helsinki.
Conflict-of-interest statement: The authors have no conflicts of interest to disclose.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The guidelines of the CONSORT 2010 Statement have been adopted in this study.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Xiang-Qing Kong, MD, PhD, Full Professor, Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. kongxq@njmu.edu.cn
Telephone: +86-139-51610265
Received: August 14, 2018
Peer-review started: August 14, 2018
First decision: September 7, 2018
Revised: September 8, 2018
Accepted: November 2, 2018
Article in press: November 2, 2018
Published online: November 26, 2018
Processing time: 103 Days and 16.7 Hours
Core Tip

Core tip: The management of intermediate coronary lesions (ICL), defined as a diameter stenosis of 40% to 70%, remains a therapeutic dilemma. The 2-dimensional representation of the arterial lesion by angiography is limited in guiding therapy. Frequency-domain optical coherence tomography (FD-OCT) is an ultra-high resolution imaging technique that enables a detailed evaluation of the coronary lumen. Despite its undebatable superiority over angiography and other intravascular imaging techniques, the benefit of FD-OCT over its procedural risks in clinical practice is uncertain. The current study is the first to date to investigate whether FD-OCT is safe and effective in the evaluation of ICL, in guiding treatment, and optimizing procedural outcomes.