Published online Dec 26, 2023. doi: 10.4330/wjc.v15.i12.633
Peer-review started: September 5, 2023
First decision: October 9, 2023
Revised: October 15, 2023
Accepted: November 30, 2023
Article in press: November 30, 2023
Published online: December 26, 2023
Processing time: 110 Days and 21.7 Hours
Coronary artery disease (CAD) is a global health concern that often leads to severe cardiovascular mortality. Refractory angina pectoris, a consequential manifestation of CAD, necessitates competent drug treatments. Two potential treatments include a traditional Chinese medicine known as Pericarpium Trichosanthis and a medication named nicorandil.
This research was driven by the need to investigate effective therapeutic procedures for elderly patients suffering from refractory angina pectoris due to CAD.
The primary objective for this research was to scrutinize the therapeutic impacts of a combined treatment, namely, Pericarpium Trichosanthis injection and nicorandil, on elderly patients with refractory angina pectoris caused by CAD.
The study was performed as a retrospective study involving 130 patients diagnosed with refractory CAD; they were divided into control and intervention groups using digital randomization. While the control group received a routine treatment, the intervention group was subjected to the combined treatment of Pericarpium Trichosanthis injection and nicorandil.
The patients in the study group demonstrated significant enhancements in heart performance and lifestyle quality. Few patients experienced headaches, but no severe side-effects were observed. No drug-related adverse reactions were noted upon follow-up.
The combined treatment of Pericarpium Trichosanthis injection and nicorandil substantially surpasses conventional treatment methods in managing symptoms and heart functionality among elderly patients suffering from refractory angina pectoris.
The beneficial findings of the present study pave the way towards further exploring this combined treatment’s potential varying application for CAD and its consequent complications, ultimately improving patient wellness and prolonging life spans. Promisingly, it may add a significant contribution to personalized treatment approaches for CAD patients.