Abe T, Eyituoyo HO, De Allie G, Olanipekun T, Effoe VS, Olaosebikan K, Mather P. Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus. World J Cardiol 2021; 13(1): 11-20 [PMID: 33552399 DOI: 10.4330/wjc.v13.i1.11]
Corresponding Author of This Article
Temidayo Abe, MD, Staff Physician, Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, United States. tabe@msm.edu
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Jan 26, 2021; 13(1): 11-20 Published online Jan 26, 2021. doi: 10.4330/wjc.v13.i1.11
Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus
Temidayo Abe, Harry Onoriode Eyituoyo, Gabrielle De Allie, Titilope Olanipekun, Valery Sammah Effoe, Kikelomo Olaosebikan, Paul Mather
Temidayo Abe, Gabrielle De Allie, Titilope Olanipekun, Department of Internal Medicine, Morehouse School of Medicine, Atlanta, GA 30310, United States
Harry Onoriode Eyituoyo, Department of Internal Medicine, Mercer University School of Medicine, Macon, GA 31207, United States
Valery Sammah Effoe, Department of Cardiovascular Disease, Morehouse School of Medicine, Atlanta, GA 30310, United States
Kikelomo Olaosebikan, Department of Medicine, University of Debrecen Medical and Health Science Center, Debrecen 4032, Hungary
Paul Mather, Department of Cardiovascular Disease, University of Pennsylvania, Pennsylvania, PA 19104, United States
Author contributions: Abe T and Eyituoyo HO contributed to study conception, interpretation of results, and manuscript write up; De Allie G, Olanipekun T and Olaosebikan K contributed to interpretation of results and manuscript write up; Effoe VS and Mather P contributed to study conception and critical review; all authors have read and approved the final manuscript.
Institutional review board statement: Data from this study used de-identified data from the National Inpatient Sample Database. A publicly available all-payer inpatient care database in the United States. Institutional Review Board Approval Form or Document is not required.
Informed consent statement: Data from this study used de-identified data from the National Inpatient Sample Database. A publicly available all-payer inpatient care database in the United States. Informed patient consent is not required.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Temidayo Abe, MD, Staff Physician, Department of Internal Medicine, Morehouse School of Medicine, 720 Westview Dr SW, Atlanta, GA 30310, United States. tabe@msm.edu
Received: September 29, 2020 Peer-review started: September 29, 2020 First decision: December 7, 2020 Revised: December 18, 2020 Accepted: December 28, 2020 Article in press: December 28, 2020 Published online: January 26, 2021 Processing time: 107 Days and 17.1 Hours
ARTICLE HIGHLIGHTS
Research background
There is a lack of data on the clinical outcomes in patients with native valve infective endocarditis (NVIE) and diabetes mellitus (DM).
Research motivation
Previous studies looking at DM and infective endocarditis (IE) have included analyses that combine NVIE and prosthetic valve IE.
Research objectives
In this study, aim to investigate the temporal trends in the prevalence of DM in NVIE and investigate the impact of DM on NVIE outcomes.
Research methods
The National Inpatient Sample 2004–2014 was queried. Cochrane Armitage test was used for trend analysis. Propensity match scoring and multivariate logistic regression were used to investigate study outcomes (Supplementary Table 2).
Research results
We identified 76385 patients with NVIE, of which 21284 (28%) had DM. Patients with DM had more comorbidities, were more likely to have staphylococcus infection, and less likely to undergo surgical valve replacement. In-hospital mortality, and IE related complications such as stroke, acute heart failure, cardiogenic shock, septic shock, and atrioventricular block, were significantly higher in patients with DM. Independent predictors of mortality in NVIE patients with DM include hemodialysis, congestive heart failure, atrial fibrillation, staphylococcus aureus, and older age.
Research conclusions
There is an increasing prevalence of DM in NVIE and it is associated with poorer outcomes.
Research perspectives
Further studies are crucial to identify the clinical, and sociodemographic contributors to this trend and develop strategies to mitigate its attendant risk.
