Wedin JO, Nyberg NS, Henriksson AE. Impact of training specificity on exercise-induced cardiac troponin elevation in professional athletes: A pilot study. World J Cardiol 2020; 12(1): 35-43 [PMID: 31984126 DOI: 10.4330/wjc.v12.i1.35]
Corresponding Author of This Article
Anders E Henriksson, MD, PhD, Professor, Department of Clinical Chemistry, Sundsvall County Hospital, Sundsvall 851 86, Sweden. anders.henriksson@rvn.se
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Jan 26, 2020; 12(1): 35-43 Published online Jan 26, 2020. doi: 10.4330/wjc.v12.i1.35
Impact of training specificity on exercise-induced cardiac troponin elevation in professional athletes: A pilot study
Johan O Wedin, Nicolena S Nyberg, Anders E Henriksson
Johan O Wedin, Department of Clinical Physiology, Sundsvall County Hospital, Sundsvall 851 86, Sweden
Johan O Wedin, Nicolena S Nyberg, Anders E Henriksson, Department of Clinical Chemistry, Sundsvall County Hospital, Sundsvall 851 86, Sweden
Anders E Henriksson, Department of Natural Sciences, Mid Sweden University, Sundsvall 851 70, Sweden
Author contributions: Wedin JO and Henriksson AE were equally involved in designing the study, collecting and analyzing the data, and preparing the manuscript; Wedin JO, Nyberg NS, and Henriksson AE reviewed and revised the final version of the manuscript.
Institutional review board statement: Please see the uploaded files where you can find the approved Institutional Review Board Statement.
Informed consent statement: Please see the uploaded files where we attached the informed consent forms for all participants.
Conflict-of-interest statement: The authors report no relevant conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Anders E Henriksson, MD, PhD, Professor, Department of Clinical Chemistry, Sundsvall County Hospital, Sundsvall 851 86, Sweden. anders.henriksson@rvn.se
Received: May 31, 2019 Peer-review started: June 4, 2019 First decision: August 2, 2019 Revised: September 20, 2019 Accepted: October 14, 2019 Article in press: October 15, 2019 Published online: January 26, 2020 Processing time: 208 Days and 19.3 Hours
ARTICLE HIGHLIGHTS
Research background
Release of biomarkers of myocardial damage such as cardiac troponins (cTns) is common after strenuous endurance exercise.
Research motivation
Although it is widely recognized that continuous exercise can induce release of cTns into the bloodstream, data on intermittent exercise are scarce. Furthermore, the principle of training specificity has never been investigated.
Research objectives
This study examined how training specificity impacts high-sensitivity cardiac troponin T (hs-cTnT) release.
Research methods
In this observational study, nine professional floorball players performed two different exercise tests: A continuous incremental cycle ergometer test and a Yo-Yo Intermittent Recovery 2 (Yo-Yo IR2) test. Serial assessment of hs-cTnT was performed after the cycle ergometer test and the Yo-Yo IR2 test (baseline, 0, 2, 6, and 24 h).
Research results
No hs-cTnT elevation above the myocardial damage cutoff (≥ 14 ng/L) was shown after the cycle ergometer test, whereas hs-cTnT levels rose over the cutoff in three of nine participants after the Yo-Yo IR2 test. The hs-cTnT levels peaked at 6 h after both tests, but were significantly higher after the Yo-Yo IR2 test compared to the cycle ergometer test (median hs-cTnT concentration 10.6 ng/L vs 7.8 ng/L, P = 0.038). All levels returned to baseline within 24 h.
Research conclusions
High-sensitivity cardiac troponin T was significantly elevated after intermittent but not continuous exercise.
Research perspectives
The principle of training specificity should be considered when designing future studies and sampling should continue at least 24 h post-exercise to avoid misinterpretation of hs-cTnT elevation.
