Ganzetti G, Campanati A, Molinelli E, Offidani A. Psoriasis, non-alcoholic fatty liver disease, and cardiovascular disease: Three different diseases on a unique background. World J Cardiol 2016; 8(2): 120-131 [PMID: 26981209 DOI: 10.4330/wjc.v8.i2.120]
Corresponding Author of This Article
Dr. Giulia Ganzetti, MD, PhD, Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Via Conca, 71, 60126 Ancona, Italy. giulia.ganzetti@alice.it
Research Domain of This Article
Dermatology
Article-Type of This Article
Topic Highlight
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Feb 26, 2016; 8(2): 120-131 Published online Feb 26, 2016. doi: 10.4330/wjc.v8.i2.120
Psoriasis, non-alcoholic fatty liver disease, and cardiovascular disease: Three different diseases on a unique background
Giulia Ganzetti, Anna Campanati, Elisa Molinelli, Annamaria Offidani
Giulia Ganzetti, Anna Campanati, Elisa Molinelli, Annamaria Offidani, Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, 60126 Ancona, Italy
Author contributions: Ganzetti G, Campanati A and Molinelli E wrote the paper; Offidani A supervised the work.
Conflict-of-interest statement: All authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Giulia Ganzetti, MD, PhD, Dermatological Unit, Department of Clinical and Molecular Sciences, Polytehnic Marche University, Via Conca, 71, 60126 Ancona, Italy. giulia.ganzetti@alice.it
Telephone: +39-71-5965686 Fax: +39-71-5963446
Received: April 28, 2015 Peer-review started: May 6, 2015 First decision: July 22, 2015 Revised: October 8, 2015 Accepted: December 17, 2015 Article in press: December 18, 2015 Published online: February 26, 2016 Processing time: 299 Days and 14.6 Hours
Abstract
Psoriasis is a chronic inflammatory immune-mediated skin disease, frequently associated with systemic comorbidities. According to recent data, patients with psoriasis show a greater prevalence of metabolic syndrome, which confers a higher cardiovascular risk. The link between these pathological conditions appears to be a chronic low-grade inflammatory status. The aim of this review is to focus on the multiple epidemiological and physio-pathogenetic aspects linking non-alcoholic fatty liver disease, psoriasis, and cardiovascular disease.
Core tip: The review focuses on recent scientific data regarding the multiple physio-pathogenetic aspects of the possible link between psoriasis, non-alcoholic fatty liver disease, and cardiovascular disease. The multidisciplinary approach to psoriatic patients appears mandatory to treat concomitant psoriasis-related comorbidity, and the risk/benefit of both biologic and non-biologic therapies should be evaluated.
