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World J Cardiol. Sep 26, 2014; 6(9): 890-907
Published online Sep 26, 2014. doi: 10.4330/wjc.v6.i9.890
Metabolic syndrome in hypertensive patients: An unholy alliance
Giuseppe Mulè, Ilenia Calcaterra, Emilio Nardi, Giovanni Cerasola, Santina Cottone
Giuseppe Mulè, Ilenia Calcaterra, Emilio Nardi, Giovanni Cerasola, Santina Cottone, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Unit of Nephrology and Hypertension, European Society of Hypertension Excellence Centre, Università di Palermo, 90146 Palermo, Italy
Author contributions: Mulè G and Calcaterra I designed and wrote the paper; Nardi E helped to write the section of the paper regarding cardiac organ damage; Cerasola G and Cottone S helped to write the section of the paper regarding renal damage and therapeutic implications.
Correspondence to: Giuseppe Mulè, MD, Dipartimento Biomedico di Medicina Interna e Specialistica (DIBIMIS), Unit of Nephrology and Hypertension, European Society of Hypertension Excellence Centre, Università di Palermo, Via Monte San Calogero 129, 90146 Palermo, Italy. giuseppe.mule@unipa.it
Telephone: +39-091-6554578 Fax: +39-091-6554338
Received: March 29, 2014
Revised: May 13, 2014
Accepted: July 18, 2014
Published online: September 26, 2014
Processing time: 182 Days and 11.3 Hours
Abstract

For many years, it has been recognized that hypertension tends to cluster with various anthropometric and metabolic abnormalities including abdominal obesity, elevated triglycerides, reduced high-density lipoprotein cholesterol, glucose intolerance, insulin resistance and hyperuricemia. This constellation of various conditions has been transformed from a pathophysiological concept to a clinical entity, which has been defined metabolic syndrome (MetS). The consequences of the MetS have been difficult to assess without commonly accepted criteria to diagnose it. For this reason, on 2009 the International Diabetes Federation, the American Heart Association and other scientific organizations proposed a unified MetS definition. The incidence of the MetS has been increasing worldwide in parallel with an increase in overweight and obesity. The epidemic proportion reached by the MetS represents a major public health challenge, because several lines of evidence showed that the MetS, even without type 2 diabetes, confers an increased risk of cardiovascular morbidity and mortality in different populations including also hypertensive patients. It is likely that the enhanced cardiovascular risk associated with MetS in patients with high blood pressure may be largely mediated through an increased prevalence of preclinical cardiovascular and renal changes, such as left ventricular hypertrophy, early carotid atherosclerosis, impaired aortic elasticity, hypertensive retinopathy and microalbuminuria. Indeed, many reports support this notion, showing that hypertensive patients with MetS exhibit, more often than those without it, these early signs of end organ damage, most of which are recognized as significant independent predictors of adverse cardiovascular outcomes.

Keywords: Arterial hypertension; Metabolic syndrome; Target organ damage; Cardiovascular risk

Core tip: Several lines of evidence suggest that metabolic syndrome (MetS) may amplify hypertension-related target organ damage (TOD). Some of MetS components, when considered individually may have little or no influence on TOD, but when taken together may synergistically interact promoting the development of left ventricular hypertrophy, aortic stiffness and microalbuminuria. The marked tendency of hypertensive patients with MetS to develop these manifestations of subclinical organ damage, that are well-known predictors of cardiovascular events, largely explain the increased morbidity and mortality associated with the syndrome. Therefore, identifying MetS in hypertensive patients may enable the clinician to better assess the cardiovascular risk.