Case Control Study
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World J Cardiol. Jul 26, 2014; 6(7): 671-674
Published online Jul 26, 2014. doi: 10.4330/wjc.v6.i7.671
Lipid profile in children with coronary artery disease in Sindh, Pakistan
Saira Baloch, Bikha Ram Devrajani, Mohsin Ali Baloch, Mohammad Ali Pir
Saira Baloch, Bikha Ram Devrajani, Medical Research Center, Liaquat University of Medical and Health Sciences, Sindh 75000, Pakistan
Mohsin Ali Baloch, Faculty of Pharmacy, University of Sindh, Jamshoro 75000, Pakistan
Mohammad Ali Pir, Department of Community Medicine and Public Health, Liaquat University of Medical and Health Sciences, Sindh 75000, Pakistan
Author contributions: Baloch S and Devrajani BR collected, analyzed and interpreted the data, and designed the study; Baloch MA and Pir MA participated in the collection of data.
Supported by Financial help and remarkable support from MRC, LUMHS, Jamshoro, Pakistan
Correspondence to: Saira Baloch, Assistant Professor, Medical Research Center, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh 75000, Pakistan. saira.baloch@lumhs.edu.pk
Telephone: +92-22-921331617 Fax: +92-22-9213315
Received: February 25, 2014
Revised: May 16, 2014
Accepted: June 10, 2014
Published online: July 26, 2014
Processing time: 176 Days and 16.7 Hours
Abstract

AIM: To evaluate lipid profile in children with coronary artery disease (CAD) in Hyderabad, Sindh, Pakistan.

METHODS: The study included 100 children (6-15 years), of which 43 were children of young parents (one or both) with recognized CAD, while the other 57 were children with no evidence of CAD (controls). All were evaluated for fasting blood lipid profile. Blood samples were collected from patients with CAD and healthy controls and analysis of the levels of lipid profile were carried out using a kit method on Microlab 300.

RESULTS: Children with CAD had significantly higher levels of total serum cholesterol and triglycerides and decreased levels of high density lipoprotein and low density lipoprotein compared to children in the control group. Systolic and diastolic blood pressures were significantly higher, without any significant difference.

CONCLUSION: CAD risk factors are significant regarding abnormal lipid levels. Genetic tendency seems to be important in the development of CAD in children.

Keywords: Serum; Lipid profile; Coronary artery disease; Children; Sindh

Core tip: It is well known that cholesterol accumulates in the coronary wall and conditions of blood pressure are recurrently connected with coronary artery disease in early adult life.