Fácila L, Morillas P, Quiles J, Soria F, Cordero A, Mazón P, Anguita M, Martín-Luengo C, Gonzalez-Juanatey JR, Bertomeu V, Investigators OBOT&POPADIPWACS(. Prognostic significance of heart rate in hospitalized patients presenting with myocardial infarction. World J Cardiol 2012; 4(1): 15-19 [PMID: 22279600 DOI: 10.4330/wjc.v4.i1.15]
Corresponding Author of This Article
Dr. Lorenzo Fácila, Department of Cardiology, Consorcio Hospitalario General de Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain. lfacila@gmail.com
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Brief Article
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World J Cardiol. Jan 26, 2012; 4(1): 15-19 Published online Jan 26, 2012. doi: 10.4330/wjc.v4.i1.15
Prognostic significance of heart rate in hospitalized patients presenting with myocardial infarction
Lorenzo Fácila, Pedro Morillas, Juan Quiles, Federico Soria, Alberto Cordero, Pilar Mazón, Manuel Anguita, Cándido Martín-Luengo, Jose Ramón Gonzalez-Juanatey, Vicente Bertomeu, on behalf of the “The Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome” (PAMISCA) Investigators
Lorenzo Fácila, Department of Cardiology, Consorcio Hospitalario General de Valencia, 46014 Valencia, Spain
Pedro Morillas, Juan Quiles, Alberto Cordero, Vicente Bertomeu, Department of Cardiology, Hospital Universitario de San Juan, 03550 Alicante, Spain
Federico Soria, Department of Cardiology, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain
Pilar Mazón, Jose Ramón Gonzalez-Juanatey, Department of Cardiology, Hospital Clínico Universitario, Santiago de Compostela, 15706 A Coruña, Spain
Manuel Anguita, Department of Cardiology, Hospital Reina Sofía, 14004 Córdoba, Spain
Cándido Martín-Luengo, Department of Cardiology, Hospital Universitario de Salamanca, 37007 Salamanca, Spain
Author contributions: Fácila L, Morillas P, Quiles J, Cordero A and Bertomeu V contributed to data collection, data analysis and designed the study, wrote and edited the manuscript; Anguita M, Soria F, Mazón P, Martín-Luengo C and Gonzalez-Juanatey JR designed the study.
Correspondence to: Dr. Lorenzo Fácila, Department of Cardiology, Consorcio Hospitalario General de Valencia, Avenida Tres Cruces 2, 46014 Valencia, Spain. lfacila@gmail.com
Telephone: +34-96-1972000 Fax: 34-96-1972161
Received: September 25, 2011 Revised: October 29, 2011 Accepted: November 5, 2011 Published online: January 26, 2012
Abstract
AIM: To investigate the prognostic significance of resting heart rate in patients with acute coronary syndrome (ACS), independent of other known factors.
METHODS: Patients 40 years of age or older who had been admitted with acute coronary syndrome (ACS) to one of the 94 hospitals participating in the Prevalence of Peripheral Arterial Disease in Patients with Acute Coronary Syndrome (PAMISCA) study were included. Patients were divided into two groups based on their resting heart rate (HR ≥ or < 70 bpm). Complications were recording during a follow-up period of 1 year.
RESULTS: There were 1054 ACS patients analyzed (43.5% with ST segment elevation and 56.5% without elevation). Mean age was 66.6 ± 11.7 years, 70.6% were male and 29.4% of subjects were female. During follow-up, more patients in the HR ≥ 70 bpm group were hospitalized for heart failure and they also had a higher mortality rate. In the multivariate analysis, a heart rate of ≥ 70 bpm was independently related to overall mortality during the follow-up period (hazard ratio 2.5; 95% confidence interval, 1.26-4.97, P = 0.009).
CONCLUSION: A resting heart rate ≥ 70 bpm in patients who survive an ACS is an indicator of a high risk of suffering cardiovascular events during follow-up.
