Guarita-Souza LC, Francisco JC, Simeoni R, Faria-Neto JR, Carvalho KAT. Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies. World J Cardiol 2011; 3(3): 93-97 [PMID: 21503169 DOI: 10.4330/wjc.v3.i3.93]
Corresponding Author of This Article
Luiz César Guarita-Souza, MD, PhD, Professor of Medicine, Department of Post Graduation Surgery, Pontifical Catholic University of Parana, 81200-525 Curitiba Pr, Brazil. guaritasouzalc@hotmail.com
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Review
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World J Cardiol. Mar 26, 2011; 3(3): 93-97 Published online Mar 26, 2011. doi: 10.4330/wjc.v3.i3.93
Benefit of stem cells and skeletal myoblast cells in dilated cardiomyopathies
Luiz César Guarita-Souza, Júlio César Francisco, Rossana Simeoni, Jose Rocha Faria-Neto, , Katherine Athayde Teixeira de Carvalho
Luiz César Guarita-Souza, Júlio César Francisco, Rossana Simeoni, Jose Rocha Faria-Neto, Department of Post Graduation Surgery, Pontifical Catholic University of Parana, 81200-525 Curitiba Pr, Brazil
Katherine Athayde Teixeira de Carvalho, The Pelé Pequeno Príncipe Institute, Child and Adolescent Health Research and Pequeno Príncipe Faculty, 81200-525 Curitiba Pr, Brazil
Author contributions: All authors contributed equally to the article.
Correspondence to: Luiz César Guarita-Souza, MD, PhD, Professor of Medicine, Department of Post Graduation Surgery, Pontifical Catholic University of Parana, 81200-525 Curitiba Pr, Brazil. guaritasouzalc@hotmail.com
Telephone: +55-41-84177188 Fax: +55-41-32711657
Received: January 15, 2011 Revised: March 2, 2011 Accepted: March 9, 2011 Published online: March 26, 2011
Abstract
Although some authors suggest that there is mitotic division in the heart, most cardiomyocytes do not have the capacity to regenerate after myocardial infarction and when this occurs there is a deterioration of contractile function, and if the area of infarction is extensive ventricular remodeling may occur, leading to the development of heart failure. Cell transplantation into the myocardium with the goal of recovery of cardiac function has been extensively studied in recent years. The effects of cell therapy are based directly on the cell type used and the type of cardiac pathology. For myocardial ischemia in the hibernating myocardium, bone marrow cells have functional benefits, however these results in transmural fibrosis are not evident. In these cases there is a benefit of implantation with skeletal myoblasts, for treating the underlying cause of disease, the loss of cell contractility.
