Schwartzenberg S, Afek A, Charach G, Rubinstein A, Ben-Shoshan Y, Kissil S, Maisel-Auslender S, Keren G, George J. Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome. World J Cardiol 2010; 2(9): 299-304 [PMID: 21160606 DOI: 10.4330/wjc.v2.i9.299]
Corresponding Author of This Article
Jacob George, MD, Professor, Department of Cardiology, Kaplan Medical Center, affiliated to the Hebrew University, Rehovot 76100, Israel. kobige@clalit.org.il
Article-Type of This Article
Brief Article
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World J Cardiol. Sep 26, 2010; 2(9): 299-304 Published online Sep 26, 2010. doi: 10.4330/wjc.v2.i9.299
Comparative analysis of the predictive power of different endothelial progenitor cell phenotypes on cardiovascular outcome
Shmuel Schwartzenberg, Arnon Afek, Gideon Charach, Ardon Rubinstein, Yossi Ben-Shoshan, Sarina Kissil, Sofia Maisel-Auslender, Gad Keren, Jacob George
Shmuel Schwartzenberg, Jacob George, Department of Cardiology, Kaplan Medical Center, affiliated to the Hebrew University, Rehovot 76100, Israel
Arnon Afek, Gideon Charach, Ardon Rubinstein, Yossi Ben-Shoshan, Sarina Kissil, Sofia Maisel-Auslender, Gad Keren, Department of Cardiology, Tel Aviv Sourasky Medical Center, Affiliated to the Tel Aviv University, Sackler School of Medicine, Tel Aviv 64239, Israel
Author contributions: George J planed the research; Ben-Shoshan Y, Kissil S and Maisel-Auslender S collected the data; Schwartzenberg S and Maisel-Auslender S analyzed the data; Schwartzenberg S and George J wrote the article; George J reviewed the article; Afek A, Charach G, Rubinstein A and Keren G revised the article.
Correspondence to: Jacob George, MD, Professor, Department of Cardiology, Kaplan Medical Center, affiliated to the Hebrew University, Rehovot 76100, Israel. kobige@clalit.org.il
Telephone: +972-8-9441335 Fax: +972-8-9441590
Received: July 2, 2010 Revised: September 15, 2010 Accepted: September 21, 2010 Published online: September 26, 2010
Abstract
AIM: To compare the predictive power of different endothelial progenitor cell (EPC) phenotypic markers for future cardiovascular events.
METHODS: Peripheral blood was collected from 76 consecutive patients with acute coronary syndromes (ACS) who underwent percutaneous coronary intervention in our institute. The various EPC phenotypes of peripheral blood mononuclear cells were CD34+CD133+, CD34+KDR+, and CD 133+KDR+. The outcome endpoint included cardiovascular mortality, recurrent ACS, and hospitalization for decompensated heart failure during a 24-mo follow-up period.
RESULTS: CD34+CD133+ cells (P = 0.034), but not CD34+KDR+ (P = 0.35) or CD 133+KDR+ cells (P = 0.19), were found to predict recurrent ACS. We found no correlation between EPCs measured by any of the three phenotypic combinations of accepted CD markers and the total combination of these separate outcomes.
CONCLUSION: The EPC CD34+CD133+ phenotype, but not the CD34+KDR+ or the CD 133+KDR+ phenotypes, is predictive of future adverse cardiovascular outcomes.
