Oliviero U, Bonadies G, Bosso G, Foggia M, Apuzzi V, Cotugno M, Valvano A, Leonardi E, Borgia G, Castello G, Napoli R, Saccà L. Impaired diastolic function in naïve untreated human immunodeficiency virus infected patients. World J Cardiol 2010; 2(4): 98-103 [PMID: 21160704 DOI: 10.4330/wjc.v2.i4.98]
Corresponding Author of This Article
Ugo Oliviero, MD, Department of Internal Medicine, University Federico II, Via S. Pansini, 5, 80131 Naples, Italy. ugo.oliviero@unina.it
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Brief Article
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World J Cardiol. Apr 26, 2010; 2(4): 98-103 Published online Apr 26, 2010. doi: 10.4330/wjc.v2.i4.98
Impaired diastolic function in naïve untreated human immunodeficiency virus infected patients
Ugo Oliviero, Giovanni Bonadies, Giorgio Bosso, Maria Foggia, Valentina Apuzzi, Mariarosaria Cotugno, Antonio Valvano, Enrico Leonardi, Guglielmo Borgia, Giuseppe Castello, Raffaele Napoli, Luigi Saccà
Ugo Oliviero, Giorgio Bosso, Valentina Apuzzi, Antonio Valvano, Raffaele Napoli, Luigi Saccà, Department of Internal Medicine, University Federico II, 80131 Naples, Italy
Giovanni Bonadies, Maria Foggia, Mariarosaria Cotugno, Guglielmo Borgia, Department of Infectious Diseases, University Federico II, 80131 Naples, Italy
Enrico Leonardi, Giuseppe Castello, National Cancer Institute, G. Pascale Foundation, 80131 Naples, Italy
Author contributions: All authors made substantial contributions to the conception and design of the study; Bonadies G, Foggia M and Cotugno M enrolled HIV patients in the study; Apuzzi V and Oliviero U performed the echocardiographic evaluations; Bosso G and Valvano A provided statistical analysis and interpretation of data; Leonardi E and Castello G collected the laboratory data were collected; Oliviero U wrote the article; Borgia G, Napoli R and Saccà L revised the article.
Correspondence to: Ugo Oliviero, MD, Department of Internal Medicine, University Federico II, Via S. Pansini, 5, 80131 Naples, Italy. ugo.oliviero@unina.it
Telephone: +39-81-7463369 Fax: +39-81-7463369
Received: February 18, 2010 Revised: April 6, 2010 Accepted: April 9, 2010 Published online: April 26, 2010
Abstract
AIM: To evaluate cardiac function and structure in untreated human immunodeficiency virus (HIV) patients without clinical evidence of cardiovascular disease.
METHODS: Fifty-three naïve untreated HIV-infected patients and 56 healthy control subjects underwent clinical assessment, electrocardiography (ECG) and echocardiography, including tissue doppler imaging. Moreover, a set of laboratory parameters was obtained from all subjects, including HIV-RNA plasma levels, CD4 cell counts and tumor necrosis factor-α levels.
RESULTS: The two groups showed normal ECG traces and no differences regarding systolic morphologic parameters. In contrast, a higher prevalence of left ventricular diastolic dysfunction (abnormal relaxation or pseudonormal filling pattern) was found in the HIV patients (36% vs 9% in patients and controls, respectively, P <0.001).
CONCLUSION: Subclinical cardiac abnormalities appear in an early stage of the HIV infection, independent of antiretroviral therapy. The data suggest that HIV per se plays a role in the genesis of diastolic dysfunction.
