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Long term combination treatment for severe idiopathic pulmonary arterial hypertension
Flora Affuso, Plinio Cirillo, Antonio Ruvolo, Guido Carlomagno, Serafino Fazio, Department of Internal Medicine, Cardiovascular and Immunologic Sciences, University of Naples Federico II School of Medicine, via S. Pansini 5, 80131 Naples, Italy
Author contributions: Affuso F performed clinical follow-up, analysis of data, manuscript drafting and review; Cirillo P performed right heart catheterization and drafting of the manuscript; Ruvolo A performed FMD and lung function testing, collection and analysis of data; Carlomagno G performed clinical follow-up, echocardiograms, manuscript drafting and review; Fazio S conceived the study, and was involved in the clinical follow-up and final review of manuscript.
Correspondence to: Serafino Fazio, MD, Department of Internal Medicine, Cardiovascular and Immunologic Sciences, University of Naples Federico II School of Medicine, via S. Pansini 5, 80131 Naples, Italy. fazio@unina.it
Telephone: +39-81-7463737 Fax: +39-81-7463737
Received: February 18, 2010
Revised: March 17, 2010
Accepted: March 22, 2010
Published online: March 26, 2010
Revised: March 17, 2010
Accepted: March 22, 2010
Published online: March 26, 2010
Abstract
We report the long-term follow-up of 3 cases of severe idiopathic pulmonary arterial hypertension, in whom tadalafil plus sitaxentan combination therapy improved the clinical condition and exercise performance without any relevant adverse event.
Keywords: Pulmonary hypertension; Tadalafil; Sitaxentan; Endothelin receptors