Chang YC, Liu WN, Lin F, Lin GM. Mood alteration and heart rate variability in patients with cancer on treatment. World J Cardiol 2025; 17(6): 107114 [DOI: 10.4330/wjc.v17.i6.107114]
Corresponding Author of This Article
Gen-Min Lin, Director, FACC, FAHA, FESC, Department of Medicine, Hualien Armed Forces General Hospital, No. 100 Jinfeng Street, Hualien City 970, Taiwan. farmer507@yahoo.com.tw
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Jun 26, 2025; 17(6): 107114 Published online Jun 26, 2025. doi: 10.4330/wjc.v17.i6.107114
Mood alteration and heart rate variability in patients with cancer on treatment
Yun-Chen Chang, Wei-Nung Liu, Felicia Lin, Gen-Min Lin
Yun-Chen Chang, School of Nursing and Graduate Institute of Nursing, China Medical University, Taichung 406, Taiwan
Yun-Chen Chang, Department of Nursing, China Medical University Hospital, Taichung 404, Taiwan
Wei-Nung Liu, Gen-Min Lin, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan
Felicia Lin, Community Care, Minnesota Oncology, Minneapolis, MN 55404, United States
Gen-Min Lin, Department of Internal Medicine, Hualien Armed Forces General Hospital, Hualien City 970, Taiwan
Author contributions: Chang YC wrote the article; Liu WN, Lin F and Lin GM made critical revisions related to important content of the manuscript; and all authors provided approval of the final version of the article to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Gen-Min Lin, Director, FACC, FAHA, FESC, Department of Medicine, Hualien Armed Forces General Hospital, No. 100 Jinfeng Street, Hualien City 970, Taiwan. farmer507@yahoo.com.tw
Received: March 16, 2025 Revised: April 11, 2025 Accepted: April 28, 2025 Published online: June 26, 2025 Processing time: 97 Days and 2.3 Hours
Abstract
In this article, Deng and Song showed compelling evidence on the connection between heart rate variability (HRV) alterations and cancer in 127 cancer patients compared with healthy reference individuals, highlighting autonomic nervous system dysfunction as a significant physiological manifestation in cancer patients. We discussed that the reduced HRV may be associated with cancer treatments, e.g., operation, chemotherapy and pain control and psychological response such as depression and anxiety related to the affected cancer. A management such as medicine to mood disturbances related to cancer has been shown a benefit to improve HRV in cancer patients.
Core Tip: We discussed that the reduced heart rate variability may be associated with cancer treatments, e.g., operation, chemotherapy and pain control and psychological response such as depression and anxiety related to the affected cancer. A management such as medicine to mood disturbances related to cancer has been shown a benefit to improve heart rate variability in cancer patients.
