Case Report
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Feb 26, 2025; 17(2): 100952
Published online Feb 26, 2025. doi: 10.4330/wjc.v17.i2.100952
Large left atrial myxoma with synchronous laryngeal squamous cell carcinoma: A case report
Ling Zhu, Jax Yuan-Zhe Neo, Lavisha S Punjabi, Siang-Hui Lai, Yeow-Leng Chua
Ling Zhu, Jax Yuan-Zhe Neo, Yeow-Leng Chua, Department of Cardiothoracic Surgery, National Heart Centre Singapore, Singapore 169609, Singapore
Lavisha S Punjabi, Siang-Hui Lai, Department of Anatomical Pathology, Singapore General Hospital, Singapore 169856, Singapore
Author contributions: Zhu L, Neo JYZ, and Punjabi LS were responsible for administrative support; Zhu L, Neo JYZ, Punjabi LS, and Lai SH were responsible for data collection and analysis; Zhu L and Chua YL were responsible for conception and design; Zhu L, Neo JYZ, Punjabi LS, Lai SH, Chua YL were responsible for manuscript writing and final approval of manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they do not have a conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ling Zhu, MD, Department of Cardiothoracic Surgery, National Heart Centre Singapore, 5 Hospital Drive, Singapore 169609, Singapore. zhu.ling1@singhealth.com.sg
Received: August 31, 2024
Revised: January 25, 2025
Accepted: February 8, 2025
Published online: February 26, 2025
Processing time: 177 Days and 21.8 Hours
Abstract
BACKGROUND

Cardiac myxoma is a benign neoplasm and one of the most common types of primary cardiac tumors. Synchronous cardiac myxoma and other malignancies are extremely rare, and only limited cases have been reported.

CASE SUMMARY

We describe a young patient with newly diagnosed locally advanced laryngeal cancer, with a synchronous cardiac tumor detected on staging scans. An echocardiogram showed the typical appearance of myxoma in the left atrium. Early cardiac surgery was performed in view of its obstructive features and post cardiac surgery recovery was uneventful. The patient was scheduled for subsequent oncological treatment for the laryngeal cancer. However, due to rapid progression of the advanced laryngeal malignancy, he was placed on supportive care.

CONCLUSION

To our knowledge, this is the first reported case of synchronous cardiac myxoma with laryngeal malignancy. Individualized treatment strategy should be adopted to manage synchronous tumors in a multidisciplinary approach. The most life-threatening condition needs be treated first. Single resection, staged operations or simultaneous resection of both tumors have been reported with good outcomes.

Keywords: Cardiac myxoma; Laryngeal carcinoma; Synchronous tumors; Cardiac surgery; Multidisciplinary approach; Case report

Core Tip: Cardiac myxoma is the one of the most common types of primary cardiac tumors. It is most frequently located in the left atrium, and surgical resection is indicated to relieve hemodynamic obstruction or to prevent embolic events. Cases of synchronous cardiac myxoma with other malignancies have been rarely reported. Herein we report probably the first case in a patient with left atrial myxoma with concurrent locally advanced laryngeal cancer, for whom early cardiac surgery was performed. A multidisciplinary approach is crucial to manage synchronous tumors, and the most life-threatening condition needs to be treated first. Optimal results have been reported after surgical resection of myxoma. The long-term prognosis, however, is mainly determined by the nature of the concurrent malignancy.