Parvaresh H, Paczek K, Al-Bari MAA, Eid N. Mechanistic insights into fasting-induced autophagy in the aging heart. World J Cardiol 2024; 16(3): 109-117 [PMID: 38576517 DOI: 10.4330/wjc.v16.i3.109]
Corresponding Author of This Article
Nabil Eid, MD, PhD, Academic Editor, Associate Professor, Lecturer, Department of Anatomy, Division of Human Biology, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Research Domain of This Article
Cell Biology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Mar 26, 2024; 16(3): 109-117 Published online Mar 26, 2024. doi: 10.4330/wjc.v16.i3.109
Mechanistic insights into fasting-induced autophagy in the aging heart
Hannaneh Parvaresh, Katarzyna Paczek, Md Abdul Alim Al-Bari, Nabil Eid
Hannaneh Parvaresh, Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad 9177948974, Iran
Katarzyna Paczek, Department of Chiropractic, International Medical University, Kuala Lumpur 57000, Malaysia
Md Abdul Alim Al-Bari, Department of Pharmacy, University of Rajshahi, Rajshahi 6205, Bangladesh
Nabil Eid, Department of Anatomy, Division of Human Biology, School of Medicine, International Medical University, Kuala Lumpur 57000, Malaysia
Author contributions: Parvaresh H and Eid N wrote the paper; Al-Bari MAA and Paczek K edited and revised it.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Nabil Eid, MD, PhD, Academic Editor, Associate Professor, Lecturer, Department of Anatomy, Division of Human Biology, School of Medicine, International Medical University, Bukit Jalil, Kuala Lumpur 57000, Malaysia. nabilsaleheid@imu.edu.my
Received: December 15, 2023 Peer-review started: December 15, 2023 First decision: January 25, 2024 Revised: February 1, 2024 Accepted: March 4, 2024 Article in press: March 4, 2024 Published online: March 26, 2024
Abstract
Autophagy is a prosurvival mechanism for the clearance of accumulated abnormal proteins, damaged organelles, and excessive lipids within mammalian cells. A growing body of data indicates that autophagy is reduced in aging cells. This reduction leads to various diseases, such as myocardial hypertrophy, infarction, and atherosclerosis. Recent studies in animal models of an aging heart showed that fasting-induced autophagy improved cardiac function and longevity. This improvement is related to autophagic clearance of damaged cellular components via either bulk or selective autophagy (such as mitophagy). In this editorial, we summarize the mechanisms of autophagy in normal and aging hearts. In addition, the protective effect of fasting-induced autophagy in cardiac aging has been highlighted.
Core Tip: Autophagy is an essential mechanism for the clearance of harmful cellular components, which accumulate with age. However, autophagic machinery decreases with age, resulting in various diseases, such as cardiac hypertrophy. Recently, fasting-induced autophagy has been reported to improve cardiac function in animal models of aging via normalization of defective autophagic machinery. Therefore, autophagy is an important target for the prevention of cardiac pathologies in the geriatric population.
