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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Molecular and metabolic landscape of adenosine triphosphate-induced cell death in cardiovascular disease
Wei Wang, Xue-Mei Wang, Hao-Long Zhang, Rui Zhao, Yong Wang, Hao-Ling Zhang, Zhi-Jing Song
Wei Wang, College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Xue-Mei Wang, College of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 73000, Gansu Province, China
Hao-Long Zhang, University Sains Malaysia, Advanced Medical and Dental Institute, Penang 13200, Malaysia
Rui Zhao, Zhi-Jing Song, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Yong Wang, Department of Pathology Center, Gansu University of Chinese Medicine, Lanzhou 730000, Gansu Province, China
Hao-Ling Zhang, Department of Biomedical Science, Advanced Medical and Dental Institute, University Sains Malaysia, Penang 13200, Malaysia
Co-corresponding authors: Hao-Ling Zhang and Zhi-Jing Song.
Author contributions: Wang W, Wang XM, Zhang HL, Zhao R, and Wang Y completed the first draft of the paper. Zhang HL and Song ZJ played pivotal roles in the research design, guiding the research group and coordinating the collaborative efforts of all authors, providing detailed guidance, and revising the paper; they are co-corresponding author of this manuscript.
Supported by National Natural Science Foundation of China, No. 81960877; University Innovation Fund of Gansu Province, No. 2021A-076; Gansu Province Science and Technology Plan, No. 21JR7RA561; Natural Science Foundation of Gansu Province, No. 21JR1RA267 and No. 24JRRA1020; Education Technology Innovation Project of Gansu Province, No. 2022A-067; Open Project of Key Laboratory of Dunhuang Medicine and Transformation of Ministry of Education, No. DHYX21-07, No. DHYX22-05, and No. DHYX21-01; and Gansu Province Joint Research Fund Project, No. 24JRRA878.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Zhi-Jing Song, PhD, Professor, Clinical College of Chinese Medicine, Gansu University of Chinese Medicine, No. 35 Dingxi East Road, Chengguan District, Lanzhou 730000, Gansu Province, China.
songzhijing2020@163.com
Received: June 5, 2024
Revised: October 4, 2024
Accepted: November 1, 2024
Published online: December 26, 2024
Processing time: 174 Days and 5.4 Hours
The maintenance of intracellular and extracellular adenosine triphosphate (ATP) levels plays a pivotal role in cardiac function. In recent years, burgeoning attention has been directed towards ATP-induced cell death (AICD), revealing it as a distinct cellular demise pathway triggered by heightened extracellular ATP concentrations, distinguishing it from other forms of cell death such as apoptosis and necrosis. AICD is increasingly acknowledged as a critical mechanism mediating the pathogenesis and progression of various cardiovascular maladies, encompassing myocardial ischemia-reperfusion injury, sepsis-induced cardiomyopathy, hypertrophic cardiomyopathy, arrhythmia, and diabetic cardiomyopathy. Consequently, a comprehensive understanding of the molecular and metabolic underpinnings of AICD in cardiac tissue holds promise for the prevention and amelioration of cardiovascular diseases. This review first elucidates the vital physiological roles of ATP in the cardiovascular system, subsequently delving into the intricate molecular mechanisms and metabolic signatures governing AICD. Furthermore, it addresses the potential therapeutic targets implicated in mitigating AICD for treating cardiovascular diseases, while also delineating the current constraints and future avenues for these innovative therapeutic targets, thereby furnishing novel insights and strategies for the prevention and management of cardiovascular disorders.
Core Tip: Understanding the mechanisms behind adenosine triphosphate (ATP)-induced cell death (AICD) is crucial for addressing various cardiovascular diseases. AICD, triggered by elevated extracellular ATP levels, differs from other forms of cell death and has emerged as a significant contributor to conditions such as myocardial ischemia-reperfusion injury, sepsis-induced cardiomyopathy, and diabetic cardiomyopathy. This review explores the physiological roles of ATP in the cardiovascular system and delves into the molecular and metabolic mechanisms underlying AICD. Identifying therapeutic targets to mitigate AICD holds promise for treating cardiovascular diseases, although challenges remain. This review provides valuable insights and strategies for preventing and managing cardiovascular disorders.
