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©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
Left bundle branch pacing vs biventricular pacing in heart failure patients with left bundle branch block: A systematic review and meta-analysis
Farah Yasmin, Abdul Moeed, Rohan Kumar Ochani, Hamna Raheel, Malik Ali Ehtsham Awan, Ayesha Liaquat, Arisha Saleem, Muhammad Aamir, Nael Hawwa, Salim Surani
Farah Yasmin, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06511, United States
Abdul Moeed, Hamna Raheel, Malik Ali Ehtsham Awan, Ayesha Liaquat, Arisha Saleem, Department of Medicine, Dow University of Health Science, Karachi 74200, Sindh, Pakistan
Rohan Kumar Ochani, Department of Medicine, SUNNY Upstate Medical University, Syracuse, NY 13210, United States
Muhammad Aamir, Nael Hawwa, Department of Cardiovascular Medicine, Lehigh Valley Heart and Vascular Institute, Allentown, PA 18105, United States
Nael Hawwa, Department of Medicine, Cleveland Clinic, Cleveland, OH 44195, United States
Salim Surani, Department of Medicine & Pharmacology, Texas A&M University, College Station, TX 77843, United States
Author contributions: Yasmin F, Moeed A, Ochani RK participated in the conceptualization, data curation, investigation, methodology, project administration, resources, supervision, validation, visualization, and writing of the original draft; Raheel H, Awan MAE, Liaquat A, Saleem A were involved in project administration, and writing of the original draft; Yasmin F, Moeed A, Aamir M, Hawwa N, and Surani S were involved in the formal analysis, project administration, supervision, validation, visualization, and writing - review & editing.
Conflict-of-interest statement: None of the authors have any conflict of interest to disclose.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Salim Surani, FCCP, MD, MHSc, Academic Editor, Professor, Department of Medicine & Pharmacology, Texas A&M University, No. 40 Bizzell Street, College Station, TX 77843, United States.
srsurani@hotmail.com
Received: August 29, 2023
Peer-review started: August 29, 2023
First decision: October 24, 2023
Revised: November 21, 2023
Accepted: January 2, 2024
Article in press: January 2, 2024
Published online: January 26, 2024
Processing time: 142 Days and 14.8 Hours
BACKGROUND
Left bundle branch pacing (LBBP) is a novel pacing modality of cardiac resynchronization therapy (CRT) that achieves more physiologic native ventricular activation than biventricular pacing (BiVP).
AIM
To explore the validity of electromechanical resynchronization, clinical and echocardiographic response of LBBP-CRT.
METHODS
Systematic review and Meta-analysis were conducted in accordance with the standard guidelines as mentioned in detail in the methodology section.
RESULTS
In our analysis, the success rate of LBBP-CRT was determined to be 91.1%. LBBP-CRT significantly shortened QRS duration, with significant improvement in echocardiographic parameters, including left ventricular ejection fraction, left ventricular end-diastolic diameter and left ventricular end-systolic diameter in comparison with BiVP-CRT.
CONCLUSION
A significant reduction in New York Heart Association class and B-type natriuretic peptide levels was also observed in the LBBP-CRT group vs BiVP-CRT group. Lastly, the LBBP-CRT cohort had a reduced pacing threshold at follow-up as compared to BiVP-CRT.
Core Tip: Left bundle branch pacing (LBBP) is a unique pacing modality in cardio resynchronization therapy. LBBP-cardiac resynchronization therapy (CRT) improves the left ventricular ejection fraction, echocardiographic parameters, and clinical outcomes when compared to biventricular pacing (BiVP). It causes significant reduction in New York Heart Association class, pacing threshold and B-type natriuretic peptide. This systematic review and meta-analysis reviews and analyze the data comparing LBBP vs BiVP-CRT.
