Russo E, Russo G, Braccio M, Cassese M. Predictors of persistence of functional mitral regurgitation after cardiac resynchronization therapy: Review of literature. World J Cardiol 2022; 14(3): 170-176 [PMID: 35432771 DOI: 10.4330/wjc.v14.i3.170]
Corresponding Author of This Article
Eleonora Russo, MD, PhD, Doctor, Department of Cardiovascular Surgery, Casa Sollievo della Sofferenza Hospital, IRCCS, Viale Cappuccini 1, San Giovanni Rotondo 71013, Italy. elerusso81@hotmail.it
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Eleonora Russo, Maurizio Braccio, Mauro Cassese, Department of Cardiovascular Surgery, Casa Sollievo della Sofferenza Hospital, IRCCS, San Giovanni Rotondo 71013, Italy
Giulio Russo, Institute of Cardiology, Catholic University of the Sacred Heart, Rome 00168, Italy
Author contributions: Russo E and Russo G contributed equally to this work and performed the conceptualization and writing of the original draft; Braccio M and Cassese M contributed to writing, reviewing and editing the manuscript.
Conflict-of-interest statement: All authors declare that there are no any conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Eleonora Russo, MD, PhD, Doctor, Department of Cardiovascular Surgery, Casa Sollievo della Sofferenza Hospital, IRCCS, Viale Cappuccini 1, San Giovanni Rotondo 71013, Italy. elerusso81@hotmail.it
Received: April 18, 2021 Peer-review started: April 18, 2021 First decision: September 2, 2021 Revised: October 10, 2021 Accepted: March 4, 2022 Article in press: March 4, 2022 Published online: March 26, 2022 Processing time: 337 Days and 17 Hours
Abstract
Functional mitral regurgitation is a common finding among heart failure patients with ischemic and non-ischemic dilated cardiomyopathies. The presence of moderate or severe mitral regurgitation is associated with higher morbidity and mortality. Heart failure patients meeting electrocardiogram and left ventricle function criteria are good candidates for cardiac resynchronization therapy, which may reduce the degree of functional mitral regurgitation in the short and long term, specifically targeting myocardial dyssynchrony and inducing left ventricle reverse remodeling. In this article, we analyze data from the literature about predictors of mitral regurgitation improvement after cardiac resynchronization therapy implantation.
Core Tip: Functional mitral regurgitation is a common finding among heart failure patients and, if moderate or severe, is associated with higher morbidity and mortality. Cardiac resynchronization therapy, as a therapy for a subset of heart failure patients, may determine a reduction of the degree of functional mitral regurgitation specifically targeting myocardial dyssynchrony and inducing left ventricle reverse remodeling. Here, we analyze predictors of mitral regurgitation improvement after cardiac resynchronization therapy implantation.
