Vidal-Perez R, Vázquez-García R, Barge-Caballero G, Bouzas-Mosquera A, Soler-Fernandez R, Larrañaga-Moreira JM, Crespo-Leiro MG, Vazquez-Rodriguez JM. Diagnostic and prognostic value of cardiac imaging in amyloidosis. World J Cardiol 2020; 12(12): 599-614 [PMID: 33391613 DOI: 10.4330/wjc.v12.i12.599]
Corresponding Author of This Article
Raquel Vázquez-García, MD, Staff Physician, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña (CHUAC), As Xubias de Arriba-84, A Coruña 15006, A Coruña, Spain. raquelvazquezgarcia@outlook.com
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Dec 26, 2020; 12(12): 599-614 Published online Dec 26, 2020. doi: 10.4330/wjc.v12.i12.599
Diagnostic and prognostic value of cardiac imaging in amyloidosis
Rafael Vidal-Perez, Raquel Vázquez-García, Gonzalo Barge-Caballero, Alberto Bouzas-Mosquera, Rafaela Soler-Fernandez, Jose Maria Larrañaga-Moreira, Maria Generosa Crespo-Leiro, Jose Manuel Vazquez-Rodriguez
Rafael Vidal-Perez, Alberto Bouzas-Mosquera, Servicio de Cardiología, Unidad de Imagen y Función Cardíaca, Complexo Hospitalario Universitario A Coruña (CHUAC), Santiago de Compostela 15706, A Coruña, Spain
Raquel Vázquez-García, Rafaela Soler-Fernandez, Jose Maria Larrañaga-Moreira, Jose Manuel Vazquez-Rodriguez, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña (CHUAC), A Coruña 15006, A Coruña, Spain
Gonzalo Barge-Caballero, Maria Generosa Crespo-Leiro, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña, Unidad de Insuficiencia Cardiaca Avanzada y Trasplante Cardiaco, Instituto de Investigación Biomédica de A Coruña (INIBIC), Centro de Investigación Biomédica en Red (CIBERCV)-Instituto de Salud Carlos III, A Coruña 15006, A Coruña, Spain
Author contributions: Vidal-Perez R and Vázquez-García R contributed equally to this work; Vidal-Perez R and Vázquez-García R designed, performed the collection of the data, edited and wrote the paper; Barge-Caballero G, Bouzas-Mosquera A, Soler-Fernandez R, Larrañaga-Moreira JM, Crespo-Leiro MG and Vazquez-Rodriguez JM contributed to the critical revision and editing of the paper.
Conflict-of-interest statement: No potential conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Raquel Vázquez-García, MD, Staff Physician, Servicio de Cardiología, Complexo Hospitalario Universitario A Coruña (CHUAC), As Xubias de Arriba-84, A Coruña 15006, A Coruña, Spain. raquelvazquezgarcia@outlook.com
Received: June 25, 2020 Peer-review started: June 25, 2020 First decision: September 18, 2020 Revised: September 28, 2020 Accepted: November 17, 2020 Article in press: November 17, 2020 Published online: December 26, 2020 Processing time: 174 Days and 13.8 Hours
Abstract
Amyloidosis is an infiltrative disease caused by extracellular protein deposition that has accumulated a lot of scientific production in recent years. Different types of amyloidosis can affect the heart. Transthyretin amyloidosis and light chain amyloidosis are the two most common types of cardiac amyloidosis. These entities have a poor prognosis, so accurate diagnostic techniques are imperative for determining an early therapeutic approach. Recent advances in cardiac imaging and diagnostic strategies show that these tools are safe and can avoid the use of invasive diagnostic techniques to histological confirmation, such as endomyocardial biopsy. We performed a review on the diagnostic and prognostic implications of different cardiac imaging techniques in cardiac amyloidosis. We mainly focus on reviewing echocardiography, cardiac magnetic resonance, computed tomography and nuclear imaging techniques and the different safety measurements that can be done with each of them.
Core Tip: Cardiac amyloidosis is a disease with a poor prognosis. However, in recent years, specific therapies have been developed. When implemented in the early stages of the disease, they are associated with an improvement in the quality of life and survival. The use of cardiac magnetic resonance, echocardiography, computed tomography and nuclear imaging techniques allows an early diagnosis. In this review, we define in detail the implication of each imaging technique in cardiac amyloidosis.
