Review
Copyright ©The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Cardiol. Jun 26, 2019; 11(6): 159-170
Published online Jun 26, 2019. doi: 10.4330/wjc.v11.i6.159
Broken heart: A matter of the endoplasmic reticulum stress bad management?
Souad Belmadani, Khalid Matrougui
Souad Belmadani, Khalid Matrougui, Department of Physiological Science, Eastern Virginia Medical School, Norfolk, VA 23501, United States
Author contributions: Belmadani S and Matrougui K contributed equally to this work.
Conflict-of-interest statement: None
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author: Souad Belmadani, PhD, Assistant Professor, Department of Physiological Science, Eastern Virginia Medical School, 700 W Olney Rd, Norfolk, VA23501, United States. belmads@evms.edu
Telephone: +1-757-4465880
Received: February 23, 2019
Peer-review started: February 26, 2019
First decision: April 15, 2019
Revised: April 29, 2019
Accepted: June 12, 2019
Article in press: June 13, 2019
Published online: June 26, 2019
Processing time: 123 Days and 17.8 Hours
Abstract

Cardiovascular diseases are the number one cause of morbidity and mortality in the United States and worldwide. The induction of the endoplasmic reticulum (ER) stress, a result of a disruption in the ER homeostasis, was found to be highly associated with cardiovascular diseases such as hypertension, diabetes, ischemic heart diseases and heart failure. This review will discuss the latest literature on the different aspects of the involvement of the ER stress in cardiovascular complications and the potential of targeting the ER stress pathways as a new therapeutic approach for cardiovascular complications.

Keywords: Heart complications; Endoplasmic reticulum stress; Inflammation; Apoptosis; Autophagy

Core tip: The central mechanisms involved in heart failure, a public health crisis, remain unknown. Current therapies, in addition to their strong side effects, neither halt nor reverse heart complications. The endoplasmic reticulum (ER) stress has been shown to be involved in cardiovascular diseases. Here we analyzed the role and mechanism of the ER stress in heart failure.