Merinopoulos I, Corballis N, Eccleshall SC, Vassiliou VS. Risk of sudden cardiac death: Are coronary chronic total occlusions an additional risk factor? World J Cardiol 2018; 10(12): 250-253 [PMID: 30622683 DOI: 10.4330/wjc.v10.i12.250]
Corresponding Author of This Article
Vassilios S Vassiliou, FRCP (C), MA, MBBS, MRCP, PhD, Honorory Consultant Cardiologist, Department of Cardiology, Norwich Medical School, Floor 2, Bob Champion Research and Education Building, James Watson Road, Norwich NR4 7UQ, United Kingdom. v.vassiliou@uea.ac.uk
Research Domain of This Article
Cardiac & Cardiovascular Systems
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Cardiol. Dec 26, 2018; 10(12): 250-253 Published online Dec 26, 2018. doi: 10.4330/wjc.v10.i12.250
Risk of sudden cardiac death: Are coronary chronic total occlusions an additional risk factor?
Ioannis Merinopoulos, Natasha Corballis, Simon C Eccleshall, Vassilios S Vassiliou
Ioannis Merinopoulos, Simon C Eccleshall, Vassilios S Vassiliou, Department of Cardiology, Norfolk and Norwich University Hospital, Norwich NR4 7UY, United Kingdom
Natasha Corballis, Department of Cardiology, West Suffolk Hospital and University of East Anglia, Bury St Edmunds IP33 2QZ, United Kingdom
Vassilios S Vassiliou, Norwich Medical School, University of East Anglia, Norfolk and Norwich University Hospital, Royal Brompton Hospital and Imperial College London, Norwich NR4 7UQ, United Kingdom
Conflict-of-interest statement: The author declares no conflicts of interest regarding this paper.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Corresponding author to: Vassilios S Vassiliou, FRCP (C), MA, MBBS, MRCP, PhD, Honorory Consultant Cardiologist, Department of Cardiology, Norwich Medical School, Floor 2, Bob Champion Research and Education Building, James Watson Road, Norwich NR4 7UQ, United Kingdom. v.vassiliou@uea.ac.uk
Telephone: +44-16-03592534 Fax: +44-16-03592534
Received: September 13, 2018 Peer-review started: September 13, 2018 First decision: October 16, 2018 Revised: October 23, 2018 Accepted: November 15, 2018 Article in press: November 15, 2018 Published online: December 26, 2018 Processing time: 104 Days and 18.4 Hours
Abstract
Sudden arrhythmic cardiac death remains a significant, potentially reversible, cardiological challenge in terms of creating accurate risk prediction models. The current guidelines for implantable cardioverter defibrillator (ICD) therapy are mainly based on left ventricular ejection fraction despite its low sensitivity and specificity in predicting sudden cardiac death (SCD). Chronic total occlusions have been associated with increased mortality but further research is required to clarify if they should be incorporated in a risk model predicting SCD aiming to identify patients that would benefit from ICD therapy even with preserved ejection fraction.
Core tip: Further research is necessary in order to clarify if chronic total occlusion can be incorporated in a risk prediction model of sudden cardiac death aiming to identify patients that would benefit from implantable cardioverter defibrillator.
