Crosstalk between mitochondria and peroxisomes

Table 1 Comparison between mitochondrial and peroxisomal beta-oxidation

	Mitochondrial	Peroxisomal
Substrates	LCFA	VLCFA, branched FA, leukotrienes
Entry system	Carnitine system (including CPT1, CACT and CPT2)	ABC transporters
End products	Acetyl-CoA (and subsequently ATP)	Acetyl-CoA and MCFA (and subsequently H202)
Physiological implications	Energy production	Biosynthesis of specific fatty acids (e.g., DHA)

LCFA: Long-chain fatty acids; VLCFA: Very long chain fatty acids; FA: Fatty acids; CPT: Carnitine palmitoyltransferase; CACT: Carnitine-acylcarnitine translocase; ABC: ATP-binding cassette; MCFA: Medium-chain fatty acids; DHA: Docosahexaenoic acid.