Review
Copyright ©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 26, 2015; 6(4): 301-309
Published online Nov 26, 2015. doi: 10.4331/wjbc.v6.i4.301
Crosstalk between mitochondria and peroxisomes
Jean Demarquoy, Françoise Le Borgne
Jean Demarquoy, Françoise Le Borgne, Université de Bourgogne, UFR SVTE, 21000 Dijon, France
Author contributions: Both authors wrote this paper.
Conflict-of-interest statement: The authors declare no conflict of interest.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Jean Demarquoy, PhD, Université de Bourgogne, UFR SVTE, Bioperoxil, 6 blvd Gabriel, 21000 Dijon, France. jean.demarquoy@u-bourgogne.fr
Telephone: +33-380-396316 Fax: +33-380-396330
Received: January 21, 2015
Peer-review started: January 22, 2015
First decision: March 6, 2015
Revised: June 30, 2015
Accepted: August 10, 2015
Article in press: August 11, 2015
Published online: November 26, 2015
Processing time: 305 Days and 15.9 Hours
Abstract

Mitochondria and peroxisomes are small ubiquitous organelles. They both play major roles in cell metabolism, especially in terms of fatty acid metabolism, reactive oxygen species (ROS) production, and ROS scavenging, and it is now clear that they metabolically interact with each other. These two organelles share some properties, such as great plasticity and high potency to adapt their form and number according to cell requirements. Their functions are connected, and any alteration in the function of mitochondria may induce changes in peroxisomal physiology. The objective of this paper was to highlight the interconnection and the crosstalk existing between mitochondria and peroxisomes. Special emphasis was placed on the best known connections between these organelles: origin, structure, and metabolic interconnections.

Keywords: Peroxisome; Mitochondrion; Beta-oxidation; Reactive oxygen species; Dynamic; Fatty acids

Core tip: The goal of this review was to highlight the links between mitochondria and peroxisomes in terms of dynamic and metabolism. This review of the literature shows that these two organelles, even if they derive from distinct ancestors, share several common functions and coordinate their activities. The division of peroxisomes and mitochondria uses similar mechanisms, and autophagic processes are used to limit the number of both organelles. The metabolic implication of mitochondria and peroxisomes in fatty acid metabolism is remarkable, as these organelles use closely-related pathways for oxidizing fatty acid, but with different metabolic goals. All together, the available data suggest a major interconnection between these organelles.