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Copyright ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Nov 16, 2018; 9(2): 16-24
Published online Nov 16, 2018. doi: 10.4331/wjbc.v9.i2.16
Role of STIM1 in neurodegeneration
Carlos Pascual-Caro, Noelia Espinosa-Bermejo, Eulalia Pozo-Guisado, Francisco Javier Martin-Romero
Carlos Pascual-Caro, Noelia Espinosa-Bermejo, Francisco Javier Martin-Romero, Department of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Badajoz 06006, Spain
Eulalia Pozo-Guisado, Department of Cell Biology, School of Medicine and Institute of Molecular Pathology Biomarkers, University of Extremadura, Badajoz 06006, Spain
Supported by the Spanish Ministerio de Ciencia, Innovación y Universidades, No. BFU2017-82716-P.
Author contributions: Martin-Romero FJ wrote the initial draft; Pascual-Caro C, Espinosa-Bermejo N and Pozo-Guisado E revised and reformatted the final version of the manuscript, together with Martin-Romero FJ; all authors approved the version to be published.
Conflict-of-interest statement: The authors declare that they have no conflict of interests.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Francisco Javier Martin-Romero, PhD, Associate Professor, Department of Biochemistry and Molecular Biology, School of Life Sciences and Institute of Molecular Pathology Biomarkers, University of Extremadura, Avenida de Elvas s/n, Badajoz 06006, Spain. fjmartin@unex.es
Telephone: +34-92-4489971
Received: August 15, 2018
Peer-review started: August 17, 2018
First decision: September 11, 2018
Revised: October 8, 2018
Accepted: October 23, 2018
Article in press: October 23, 2018
Published online: November 16, 2018
Processing time: 98 Days and 21.6 Hours
Core Tip

Core tip: STIM1 is an endoplasmic reticulum protein that regulates store-operated Ca2+ entry, which is a Ca2+ influx pathway involved in a wide variety of signalling pathways. Growing evidence supports a role for this protein, STIM1, in long-term potentiation and the formation of memory. In this regard, the loss of STIM1 observed in brain tissue from Alzheimer’s disease patients risks cell viability and could be the cause of neurodegenerative diseases. This is the reason for discussing the role of STIM1 in neurodegeneration in this review.