Review
Copyright ©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. May 26, 2017; 8(2): 108-119
Published online May 26, 2017. doi: 10.4331/wjbc.v8.i2.108
Endocrine disrupting chemicals in mixture and obesity, diabetes and related metabolic disorders
Brigitte Le Magueresse-Battistoni, Emmanuel Labaronne, Hubert Vidal, Danielle Naville
Brigitte Le Magueresse-Battistoni, CarMeN Laboratory, IN SERM U1060, Faculté de Médecine Lyon-Sud, 69600 Oullins, France
Brigitte Le Magueresse-Battistoni, Emmanuel Labaronne, Hubert Vidal, Danielle Naville, Univ-Lyon, CarMeN Laboratory, INSERM U1060, INRA U1397, Université Claude Bernard Lyon1, INSA Lyon, Charles Mérieux Medical School, 69600 Oullins, France
Author contributions: Le Magueresse-Battistoni B and Naville D generated the tables and wrote the manuscript; Labaronne E and Vidal H contributed to the writing of the manuscript.
Supported by INSERM to InsermU1060; “Région Rhône-Alpes”, No. ARC 2013-ARC1 SANTE-13-018955-01 (to Labaronne E).
Conflict-of-interest statement: The authors declared no conflict of interest related to this manuscript.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Dr. Brigitte Le Magueresse-Battistoni, PhD, CarMeN Laboratory, INSERM U1060, Faculté de Médecine Lyon-Sud, Chemin du Grand Revoyet, 69600 Oullins, France. brigitte.lemagueresse@inserm.fr
Telephone: +33-42-6235919 Fax: +33-42-6235916
Received: October 21, 2016
Peer-review started: October 23, 2016
First decision: January 20, 2017
Revised: January 25, 2017
Accepted: May 3, 2017
Article in press: May 3, 2017
Published online: May 26, 2017
Processing time: 208 Days and 5.6 Hours
Core Tip

Core tip: Evidences are accumulating showing that some pollutants endowed with endocrine disrupting activities, the so-called endocrine disrupting chemicals, may contribute to the pandemic evolution of obesity and related metabolic disorders including diabetes. Within this review, we present the concept of endocrine and metabolic disruption and give an overview of the current knowledge of the field, including data from our laboratory and others, specifically focusing on the cocktail effect of pollutants which is one of the biggest concern caused by pollutants nowadays.