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©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Biol Chem. Feb 26, 2017; 8(1): 32-44
Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.32
Published online Feb 26, 2017. doi: 10.4331/wjbc.v8.i1.32
Retroviral integrase protein and intasome nucleoprotein complex structures
Julia Grawenhoff, Alan N Engelman, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA 02215, United States
Julia Grawenhoff, Alan N Engelman, Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
Author contributions: Grawenhoff J and Engelman AN conceived the review and wrote the manuscript.
Supported by United States National Institutes of Health grant , No. R01AI070042 .
Conflict-of-interest statement: Authors declare no conflicts of interest for this article.
Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Correspondence to: Alan N Engelman, PhD, Professor of Medicine, Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, 450 Brookline Avenue, CLS-1010, Boston, MA 02215, United States. alan_engelman@dfci.harvard.edu
Telephone: +1-617-6324361 Fax: +1-617-6324338
Received: November 1, 2016
Peer-review started: November 4, 2016
First decision: December 14, 2016
Revised: December 24, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: February 26, 2017
Processing time: 116 Days and 12 Hours
Peer-review started: November 4, 2016
First decision: December 14, 2016
Revised: December 24, 2016
Accepted: January 11, 2017
Article in press: January 14, 2017
Published online: February 26, 2017
Processing time: 116 Days and 12 Hours
Core Tip
Core tip: This review examines the history of retroviral integrase structural biology and covers the currently available high-resolution structures of retroviral intasomes in detail. We in particular focus on the similarities and differences among the intasome structures of prototype foamy virus, Rous sarcoma virus and mouse mammary tumor virus.